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What do systematic reviews say?

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Evidence found and GRADE certainty

633 questions · 668 findings · 122 reviews · Headline outcomes only

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No studies found 144 · 21.6%GRADE not reported 27 · 4%Very low 154 · 23.1%Low 194 · 29%Moderate 119 · 17.8%High 30 · 4.5%

Macrolides vs placebo

Severe exacerbations requiring hospitalisation over the study period · adults and children with chronic asthma

Macrolides showed no clear difference in exacerbation requiring hospitalisation Weighted mean study duration:… compared with placebo (moderate certainty).

1 finding from 1 review

Macrolides vs placebo

Serious adverse events (including mortality) · adults and children with chronic asthma

Macrolides showed no clear difference in serious adverse events (including mortality) Weighted mean study… compared with placebo (low certainty).

1 finding from 1 review

Macrolides vs placebo

Exacerbations (number of people experiencing ≥ 1 exacerbations) · adults with bronchiectasis

Macrolides probably leads to lower ≥ 1 exacerbation compared with placebo (moderate certainty).

1 finding from 1 review

Macrolides vs placebo

Exacerbation frequency · children with bronchiectasis

Macrolides may leads to lower exacerbation frequency compared with placebo (low certainty).

1 finding from 1 review

Macrolides vs placebo

Hospitalisation (any cause) · children with bronchiectasis

Macrolides showed no clear difference in hospitalisation: all‐cause compared with placebo (low certainty).

1 finding from 1 review

Macrolides vs placebo

Serious adverse events · children with bronchiectasis

Macrolides showed no clear difference in serious adverse events compared with placebo (low certainty).

1 finding from 1 review