Participants with a serious adverse event following a single dose, and after 3 to 5 days · adults with moderate or severe acute postoperative pain
1 finding from 1 review
Intervention not reported
Participants with at least 1 adverse event (all diclofenac potassium doses, 25 mg to 100 mg) · Adults with acute pain
The intervention showed no clear difference in participants with at least 1 adverse event (all diclofenac potassium… (moderate certainty).
1 finding from 1 review
Pain‐free at 2 hours · migraine headache ‐ moderate or severe pain
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Headache relief at 2 h · migraine headache ‐ moderate or severe pain
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Sustained pain‐free at 24 h · migraine headache ‐ moderate or severe pain
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Sustained headache relief at 24 h · migraine headache ‐ moderate or severe pain
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Number of participants reporting an adverse event · migraine headache ‐ moderate or severe pain
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Serious AE · migraine headache ‐ moderate or severe pain
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Total studies: 93 Total participants: 22,558 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
The intervention led to lower total studies: 93 Total participants: 22,558; GRADE not reported.
1 finding from 1 review
no estimate extracted
93 participants
GRADE not reported
Intervention not reported
Desvenlafaxine high dose RCTs: 2 Participants: 905 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
1 finding from 1 review
no estimate extracted
2 participants
Very low
Intervention not reported
Mirtazapine standard dose RCTs: 2 Participants: 457 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
1 finding from 1 review
no estimate extracted
2 participants
Very low
Intervention not reported
Duloxetine standard dose RCTs: 20 Participants: 4998 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
1 finding from 1 review
no estimate extracted
20 participants
Very low
Intervention not reported
Milnacipran standard dose RCTs: 8 Participants: 2491 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
1 finding from 1 review
no estimate extracted
8 participants
Very low
Intervention not reported
Duloxetine high dose RCTs: 10 Participants: 4000 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
1 finding from 1 review
no estimate extracted
10 participants
Very low
Intervention not reported
Duloxetine low dose RCTs: 6 Participants: 1031 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
1 finding from 1 review
no estimate extracted
6 participants
Very low
Intervention not reported
Milnacipran high dose RCTs: 7 Participants: 2837 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
1 finding from 1 review
no estimate extracted
7 participants
Very low
Intervention not reported
Amitriptyline standard dose RCTs: 10 Participants: 997 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
1 finding from 1 review
no estimate extracted
10 participants
Very low
Intervention not reported
Esreboxetine standard dose RCTs: 1 Participants: 783 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
1 finding from 1 review
no estimate extracted
1 participants
Very low