Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

157 questions · 158 findings · 44 reviews · Headline outcomes only

No studies found 25 · 15.8%GRADE not reported 7 · 4.4%Very low 40 · 25.3%Low 50 · 31.6%Moderate 33 · 20.9%High 3 · 1.9%

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Vomiting, retching, or antiemetics from 0‐2 hours · people with paracetamol (acetaminophen) overdose

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower vomiting, retching, or antiemetics from 0‐2 hours compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

1 finding from 1 review

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Vomiting, retching, or antiemetics 0‐12 hours · people with paracetamol (acetaminophen) overdose

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower vomiting, retching, or antiemetics 0‐12 hours compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

1 finding from 1 review

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Anaphylactoid symptoms · people with paracetamol (acetaminophen) overdose

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower anaphylactoid symptoms compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

1 finding from 1 review

Single foetal haemoglobin inducer at any dose or duration vs another dose or dose regimen of the same foetal haemoglobin inducer

Neutropenia · people with non‐transfusion‐dependent β‐thalassaemia

It is very uncertain whether one dose or dose regimen of a foetal haemoglobin inducer changes neutropenia (WBC < 1 × 103/μL, ANC < 0.5 × 103/μL) compared with another dose or dose regimen of the same foetal haemoglobin inducer (very low certainty).

1 finding from 1 review

Ventilation tubes vs no treatment

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether ventilation tubes changes hearing ‐ return to normal hearing Randomised by ear: normal defined… compared with no treatment (very low certainty).

1 finding from 1 review

Ventilation tubes vs myringotomy

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether ventilation tubes changes hearing ‐ return to normal *Ventilation tubes versus laser… compared with myringotomy (very low certainty).

1 finding from 1 review