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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

1,956 questions in 143 reviews · Musculoskeletal

current versions
No studies 555 · 28.4%Ungraded 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension
Function (change from baseline) SPADI 0‐100 (lower scores = better function) · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extracted1 study · 148 participantsHigh
Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension
Active shoulder abduction (change from baseline) Degrees · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extracted1 study · 148 participantsHigh
Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension
Quality of life (change from baseline) SF‐36 Physical Component Score (0‐100) (lower scores = worse quality of life) · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extracted1 study · 148 participantsHigh
Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension
Global assessment of treatment success "Success, much improved, and/or completely recovered" (self‐rated) · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
RR 1.331 study · 148 participantsHigh
Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension
Adverse events · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
RR 0.991 study · 149 participantsHigh
Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID
Participant‐reported pain relief ≥ 30% · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID
Overall pain · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID
Function (change from baseline) Shoulder Pain and Disability Questionnaire (SPADI, 0‐100) (lower scores = better function) · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extracted1 study · 119 participantsLow
Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID
Global assessment of treatment success "Disappearance of shoulder complaints or some pain/limitation which does not interfere with everyday life" · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
RR 1.451 study · 109 participantsLow
Combination of manual therapy and exercise vs glucocorticoid injection
Global assessment of treatment success Complete recovery or much improvement (self‐rated) · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
RR 0.61 study · 108 participantsModerate
Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID
Active shoulder abduction · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID
Quality of life · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID
Adverse events Pain persisting longer than 2 hours after treatment (during the 3‐week treatment period) · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
RR 8.851 study · 119 participantsLow
Combination of manual therapy and exercise vs glucocorticoid injection
Active shoulder abduction · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Combination of manual therapy and exercise vs glucocorticoid injection
Quality of life · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Combination of manual therapy and exercise vs glucocorticoid injection
Adverse events · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
RR 1.071 study · 114 participantsModerate
Combination of manual therapy, exercise, electrotherapy and placebo injection vs glucocorticoid injection
Participant‐reported pain relief ≥ 30% · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Combination of manual therapy, exercise, electrotherapy and placebo injection vs glucocorticoid injection
Overall pain (change from baseline) Shoulder Pain and Disability Questionnaire (SPADI, 0‐100) (lower scores = less pain)a · patients with adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extracted2 studies · 86 participantsLow
Low‐level laser therapy (LLLT) vs placebo
Participant‐reported pain relief ≥ 30% · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Pulsed electromagnetic field therapy (PEMF) vs placebo
Function Total recovery of joint function · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
RR 14.24 [0.91, 221.75]1 study · 32 participantsVery low
Pulsed electromagnetic field therapy (PEMF) vs placebo
Global assessment of treatment success · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Pulsed electromagnetic field therapy (PEMF) vs placebo
Active shoulder abduction · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Pulsed electromagnetic field therapy (PEMF) vs placebo
Quality of life · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Pulsed electromagnetic field therapy (PEMF) vs placebo
Adverse events · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Low‐level laser therapy (LLLT) plus exercise vs exercise
Participant‐reported pain relief ≥ 30% · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Low‐level laser therapy (LLLT) plus exercise vs exercise
Overall pain 0‐100 visual analogue scale (lower score = less pain) · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extracted1 study · 63 participantsModerate
Low‐level laser therapy (LLLT) plus exercise vs exercise
Function Shoulder Disabilty Questionnaire 0‐100 (lower scores = better function) · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extracted1 study · 63 participantsModerate
Low‐level laser therapy (LLLT) plus exercise vs exercise
Global assessment of treatment success · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Low‐level laser therapy (LLLT) plus exercise vs exercise
Active shoulder abduction Degrees · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extracted1 study · 63 participantsModerate
Low‐level laser therapy (LLLT) vs placebo
Overall pain · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Low‐level laser therapy (LLLT) plus exercise vs exercise
Quality of life · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Low‐level laser therapy (LLLT) plus exercise vs exercise
Adverse events · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extracted1 study · 63 participantsModerate
Low‐level laser therapy (LLLT) vs placebo
Function · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Low‐level laser therapy (LLLT) vs placebo
Global assessment of treatment success 'Excellent' or 'good' result (self‐rated) · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
RR 8 [2.11, 30.34]1 study · 40 participantsLow
Low‐level laser therapy (LLLT) vs placebo
Active shoulder abduction · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Low‐level laser therapy (LLLT) vs placebo
Quality of life · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Low‐level laser therapy (LLLT) vs placebo
Adverse events · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extracted1 study · 40 participantsLow
Pulsed electromagnetic field therapy (PEMF) vs placebo
Participant‐reported pain relief ≥ 30% Complete resolution of SPADI pain · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
RR 19.19 [1.25, 294.21]1 study · 32 participantsVery low
Pulsed electromagnetic field therapy (PEMF) vs placebo
Overall pain · patients with adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder) (2014) · Cochrane
no estimate extractedNRNo studies
Aquatic training vs control
Multidimensional function Self report questionnaire FIQ ‐ total (range 0 to 100, lower scores indicate greater health) · adults with fibromyalgia
Aquatic exercise training for fibromyalgia (2014) · Cochrane
no estimate extracted7 studies · 367 participantsModerate
Aquatic training vs land‐based training
Pain Self reported measures FIQ pain, SF‐36 bodily pain and VAS (transformed range 0 to 100, higher scores mean more pain) · adults with fibromyalgia
Aquatic exercise training for fibromyalgia (2014) · Cochrane
no estimate extracted4 studies · 169 participantsLow
Aquatic training vs land‐based training
Stiffness Self reported measures FIQ stiffness (0 to 100 mm) · adults with fibromyalgia
Aquatic exercise training for fibromyalgia (2014) · Cochrane
no estimate extracted1 study · 34 participantsVery low
Aquatic training vs land‐based training
Muscle strength Grip strength Kilo Pascals (kPa). Higher scores indicate greater health · adults with fibromyalgia
Aquatic exercise training for fibromyalgia (2014) · Cochrane
no estimate extracted1 study · 34 participantsVery low
Aquatic training vs land‐based training
Submaximal cardiorespiratory function Walking time (seconds required to complete 100 meters) · adults with fibromyalgia
Aquatic exercise training for fibromyalgia (2014) · Cochrane
no estimate extracted1 study · 34 participantsVery low
Aquatic training vs land‐based training
Withdrawals and adverse effects8 · adults with fibromyalgia
Aquatic exercise training for fibromyalgia (2014) · Cochrane
Risk ratio 0.91 [0.43, 1.91]4 studies · 217 participantsLow
Aquatic training vs control
Self reported physical function FIQ physical function scale and SF‐36 physical function scale (transformed range 0 to 100, lower scores indicate greater health) · adults with fibromyalgia
Aquatic exercise training for fibromyalgia (2014) · Cochrane
no estimate extracted5 studies · 285 participantsModerate
Aquatic training vs control
Pain Self reported questionnaires (i.e., FIQ pain, SF‐36 bodily pain, current pain VAS) (transformed range 0 ‐ 100, lower scores indicate greater health). · adults with fibromyalgia
Aquatic exercise training for fibromyalgia (2014) · Cochrane
no estimate extracted7 studies · 382 participantsLow
Aquatic training vs control
Stiffness Self reported questionnaire FIQ Stiffness scale (0 to 100 mm VAS, lower scores indicate greater health) · adults with fibromyalgia
Aquatic exercise training for fibromyalgia (2014) · Cochrane
no estimate extracted4 studies · 230 participantsLow
Aquatic training vs control
Muscle strength Isokinetic strength of knee extension and hand grip. Higher scores indicate greater health · adults with fibromyalgia
Aquatic exercise training for fibromyalgia (2014) · Cochrane
no estimate extracted4 studies · 152 participantsLow
Aquatic training vs control
Submaximal cardiorespiratory function 6‐minute walk test (distance in meters). Higher scores indicate greater health · adults with fibromyalgia
Aquatic exercise training for fibromyalgia (2014) · Cochrane
no estimate extracted3 studies · 213 participantsLow