Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

618 questions · 646 findings · 79 reviews · Neonatal

No studies found 73 · 11.3%GRADE not reported 29 · 4.5%Very low 145 · 22.4%Low 177 · 27.4%Moderate 173 · 26.8%High 49 · 7.6%

Community health educational intervention for family members and mothers and for mothers only (subgroup) vs control

Late neonatal mortality ‐ Intervention given to mothers only · developing countries

It is very uncertain whether community health educational intervention for family members and… changes late neonatal mortality ‐ Intervention given to mothers only compared with control (very low certainty).

1 finding from 1 review

Community health educational intervention for family members and mothers and for mothers only (subgroup) vs control

Perinatal mortality · developing countries

Community health educational intervention for family members and… may leads to lower perinatal mortality ‐ Intervention given to mothers and family members compared with control (low certainty).

2 findings from 1 review

Community health educational interventions vs control

Perinatal mortality · developing countries

Community health educational interventions probably leads to lower perinatal mortality compared with control (moderate certainty).

2 findings from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Neonatal mortality ‐ One‐to‐one counselling · developing countries

It is very uncertain whether community health educational one‐to‐one and group and both… changes neonatal mortality ‐ One‐to‐one counselling compared with control (very low certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Neonatal mortality ‐ Group counselling · developing countries

Community health educational one‐to‐one and group and both… may leads to lower neonatal mortality ‐ Group counselling compared with control (low certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Neonatal mortality · developing countries

Community health educational one‐to‐one and group and both… showed no clear difference in neonatal mortality ‐ Both group and one‐to‐one counselling compared with control (moderate certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Early neonatal mortality ‐ Group counselling · developing countries

Community health educational one‐to‐one and group and both… may leads to lower early neonatal mortality ‐ Group counselling compared with control (low certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Early neonatal mortality ‐ One‐to‐one counselling · developing countries

Community health educational one‐to‐one and group and both… may leads to higher early neonatal mortality ‐ One‐to‐one counselling compared with control (low certainty).

1 finding from 1 review

Inhaled steroids vs systemic steroids

Death or bronchopulmonary dysplasia at 36 weeks PMA · Neonates with developing BPD

Inhaled steroids showed no clear difference in death or BPD at 36 weeks' postmenstrual age compared with systemic steroids (moderate certainty).

2 findings from 1 review

Inhaled steroids vs systemic steroids

Diastolic blood pressure > 95th percentile at 7 years · Neonates with developing BPD

Inhaled steroids probably leads to lower diastolic blood pressure > 95th percentile at 7 years compared with systemic steroids (moderate certainty).

1 finding from 1 review

Inhaled steroids vs systemic steroids

General conceptual ability (GCA) score at 7 years The test has a standardisation mean of 100 and SD of 15 · Neonates with developing BPD

Inhaled steroids showed no clear difference in general conceptual ability (GCA) score at 7 years The test has a… compared with systemic steroids (moderate certainty).

1 finding from 1 review

Inhaled steroids vs systemic steroids

Systolic blood pressure > 95th percentile at 7 years · Neonates with developing BPD

Inhaled steroids showed no clear difference in systolic blood pressure > 95th percentile at 7 years compared with systemic steroids (moderate certainty).

1 finding from 1 review

Inhaled steroids vs systemic corticosteroids

BPD or death at 36 weeks' postmenstrual age№ of participants: 0 (0 RCTs) · preterm infants with respiratory distress for initial respiratory support

Inhaled steroids showed no clear difference in death or BPD at 36 weeks' postmenstrual age among all randomised compared with systemic corticosteroids (moderate certainty).

1 finding from 1 review