Findings

What do systematic reviews say?

2,256 questions · 2,339 findings · 262 reviews

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No studies found 555 · 23.7%GRADE not reported 398 · 17%Very low 572 · 24.5%Low 476 · 20.4%Moderate 240 · 10.3%High 98 · 4.2%

Intervention not reported

Change in number of hot flushes/24 h ( · perimenopausal and postmenopausal women with vasomotor symptoms

1 finding from 1 review

Relaxation for perimenopausal and postmenopausal symptoms 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 72 participants
Very low

Intervention not reported

Improvement in severity of hot flushes ( · perimenopausal and postmenopausal women with vasomotor symptoms

1 finding from 1 review

Relaxation for perimenopausal and postmenopausal symptoms 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 72 participants
Very low

Non‐steroidal antiandrogen monotherapy vs LHRH agonists or surgical castration monotherapy

Hot flashes · men with advanced prostate cancer

Non‐steroidal antiandrogen monotherapy probably leads to lower hot flashes compared with LHRH agonists or surgical castration monotherapy (moderate certainty).

1 finding from 1 review

Non‐steroidal antiandrogen monotherapy compared with luteinising hormone–releasing hormone agonists or surgical… 2014 · Cochrane Headline outcomes only
RR 0.23 [0.19, 0.27]
9 studies · 2774 participants
Moderate

Intervention not reported

Recurrent pericarditis Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) Intervention: colchicine with NSAID; Comparison: NSAID alone

The intervention probably leads to lower recurrent pericarditis Chest pain + (ECG changes +/‐… (moderate certainty).

1 finding from 1 review

Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
HR 0.37 [0.24, 0.58]
2 studies · 204 participants
Moderate

Intervention not reported

months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers)

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

1 finding from 1 review

Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
RR 0.41 [0.28, 0.61]
2 studies · 360 participants
Moderate

Intervention not reported

Acute pericarditis Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) Intervention: colchicine with NSAID; Comparison: NSAID alone

The intervention probably leads to lower acute pericarditis Chest pain + (ECG changes +/‐ echocardiographic… (moderate certainty).

1 finding from 1 review

Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
HR 0.4 [0.27, 0.61]
2 studies · 360 participants
Moderate

Intervention not reported

months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers)

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

1 finding from 1 review

Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
RR 0.28 [0.17, 0.47]
2 studies · 204 participants
Moderate

Intervention not reported

months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers)

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

1 finding from 1 review

Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
RR 0.36 [0.23, 0.56]
2 studies · 204 participants
Moderate

Intervention not reported

months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers)

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

1 finding from 1 review

Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
RR 0.38 [0.25, 0.58]
2 studies · 204 participants
Moderate

Intervention not reported

months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers)

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

1 finding from 1 review

Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
RR 0.36 [0.23, 0.58]
2 studies · 360 participants
Moderate

Intervention not reported

months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers)

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

1 finding from 1 review

Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
RR 0.4 [0.26, 0.61]
2 studies · 360 participants
Moderate

One-stage lateral sinus lift with monocortical autogenous bone blocks (iliac crest) vs Two-stage lateral sinus lift with autogenous particulate bone (iliac crest)

Prosthesis failure · Patients with 2 to 7 mm of residual alveolar bone height in the edentulous maxillary sinus floor

One-stage lateral sinus lift with monocortical autogenous bone… showed no clear difference in prosthesis failure compared with two-stage lateral sinus lift with autogenous particulate bone (iliac…; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes
3 years after loading
OR 1.00 [0.06, 17.18]
1 study · 40 participants
GRADE not reported

Bio-Oss (anorganic bovine bone) vs A different bone substitute

Prosthesis failure · Patients undergoing two-stage maxillary sinus augmentation

1 finding from 1 review

Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes
1 year after loading
Lindgren 2012 (split-mouth, 11 patients): prosthesis failures 0/11 versus 0/11; none.
1 study · 11 participants
GRADE not reported

One-stage augmentation (implants placed simultaneously) vs Two-stage augmentation (delayed implant placement)

Prosthesis failure · Patients with insufficient bone below the maxillary sinus requiring dental implants

One-stage augmentation (implants placed simultaneously) showed no clear difference in prosthesis failure compared with two-stage augmentation (delayed implant placement); GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes
1 year after loading
OR 0.35 [0.01, 6.83]
1 study · 58 participants
GRADE not reported

Hand mallet (osteotomes) vs Electric mallet

Prosthesis failure · Patients undergoing one-stage crestal maxillary sinus lift without bone grafts (baseline residual bone height about 6.5 mm)

1 finding from 1 review

Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes
19 months to 3 years after loading
Crespi 2012 (parallel, 40 per group): prosthesis failures 0/40 versus 0/40; none.
1 study · 80 participants
GRADE not reported

Maxillary sinus lift (augmentation) with long implants vs Short implants (5 to 8.5 mm) without sinus augmentation

Prosthesis failure · Patients with missing teeth and an atrophic posterior maxilla, with residual bone height between 4 and 9 mm below the maxillary sinus

Maxillary sinus lift (augmentation) with long implants showed no clear difference in prosthesis failure compared with short implants (5 to 8.5 mm) without sinus augmentation (moderate certainty).

1 finding from 1 review

Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes
median 1 year after loading
Peto OR 0.37 [0.05, 2.68]
3 studies · 109 participants
Moderate

Zygomatic implants without bone grafts (as a complete alternative to any bone augmentation procedure) vs Conventional dental implants in augmented maxillae

Prosthesis failure · Participants with an atrophic maxilla who cannot be rehabilitated with conventional dental implants due to lack of bone (including…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for replacing missing teeth: dental implants in zygomatic bone for the rehabilitation of the severely… 2013 · Cochrane All outcomes
At least 1 year in function
Summary of findings 'Zygomatic implants versus conventional implants'; Prosthesis failure: Assumed risk (conventional) Low risk population 10 per 1000, High risk population 100 per 1000; Corresponding risk (zygomatic)…
0 studies
No studies found

Immediate loading vs Early loading

Prosthesis failure · Patients who are having osseointegrated root-form dental implants

It is very uncertain whether immediate loading changes prosthesis failure compared with early loading (very low certainty).

1 finding from 1 review

Interventions for replacing missing teeth: different times for loading dental implants 2013 · Cochrane All outcomes
1 year
RR 0.69 [0.25, 1.87]
4 studies · 408 participants
Very low

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Behavioural outcomes (reported and/or other measures, e.g. data tracking toothbrushes and collecting food wrappers) · Children aged 4 to 12 years attending primary school

The review found no eligible studies for this question.

1 finding from 1 review

Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes
No other behavioural outcomes (e.g. objective toothbrush tracking or food-wrapper collection) were measured by the four included studies.
0 studies
No studies found

Locking plate vs 2 mm non-locking titanium plates

Post-operative adverse events and complications (paraesthesia, swelling, segmental mobility) · Adults (16 to 68 years) with mandibular fractures excluding condylar involvement

1 finding from 1 review

Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
Agarwal 2011: paraesthesia in one participant in the non-locking plate group (resolved by 3 months), none in the locking group; infection rates similar at 6 weeks and 3 months; post-operative swelling in 20% of both…
1 study
GRADE not reported