What do systematic reviews say?

Colloid vs crystalloid

Colloids may leads to higher pulmonary oedema compared with crystalloids (low certainty).

• Parenteral fluid regimens for improving functional outcome in people with acute stroke 2015 · Cochrane Headline outcomes only
  OR 2.34 [1.28, 4.29]
  3 studies · 730 participants
  Low

Saline vs other fluids

0.9% saline showed no clear difference in death or dependence compared with other fluid (low certainty).

• Parenteral fluid regimens for improving functional outcome in people with acute stroke 2015 · Cochrane Headline outcomes only
  OR 1.04 [0.82, 1.32]
  3 studies · 1120 participants
  Low

Saline vs other fluids

0.9% saline showed no clear difference in death compared with other fluid (low certainty).

• Parenteral fluid regimens for improving functional outcome in people with acute stroke 2015 · Cochrane Headline outcomes only
  OR 0.87 [0.67, 1.12]
  5 studies · 1760 participants
  Low

Saline vs other fluids

It is very uncertain whether 0.9% saline changes pneumonia compared with other fluid (very low certainty).

• Parenteral fluid regimens for improving functional outcome in people with acute stroke 2015 · Cochrane Headline outcomes only
  OR 2 [0.36, 11.16]
  1 study · 216 participants
  Very low

Saline vs other fluids

0.9% saline probably leads to lower pulmonary oedema compared with other fluid (moderate certainty).

• Parenteral fluid regimens for improving functional outcome in people with acute stroke 2015 · Cochrane Headline outcomes only
  OR 0.32 [0.14, 0.69]
  1 study · 424 participants
  Moderate

Intervention not reported

The intervention probably leads to lower low Hb deferral ‐ at first donation visit after commencement of… (moderate certainty).

• Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors 2014 · Cochrane Headline outcomes only
  RR 0.34 [0.21, 0.55]
  4 studies · 1194 participants
  Moderate

Intervention not reported

The intervention probably leads to lower low Hb deferral ‐ after multiple donation visits (moderate certainty).

• Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors 2014 · Cochrane Headline outcomes only
  RR 0.25 [0.15, 0.41]
  3 studies · 793 participants
  Moderate

Intervention not reported

• Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors 2014 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 847 participants
  Moderate

Intervention not reported

• Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors 2014 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 406 participants
  Moderate

Intervention not reported

• Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors 2014 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 640 participants
  Moderate

Intervention not reported

• Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors 2014 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 619 participants
  Moderate

Intervention not reported

The intervention probably leads to higher adverse effects (any) (moderate certainty).

• Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors 2014 · Cochrane Headline outcomes only
  RR 1.6 [1.23, 2.07]
  4 studies · 1748 participants
  Moderate