Cochrane · systematic review · CD009532
Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors
Smith, GA, Fisher, SA, Doree, C, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
InjuriesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 7 · 100%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Iron supplementation for iron deficiency and/or anaemia in blood donors
Population: patients with iron deficiency and/or anaemia in blood donors
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Low Hb deferral ‐ at first donation visit after commencement of treatment | RR 0.34 [0.21, 0.55] | 4 studies · 1194 participants | Moderate Downgraded: risk of bias, imprecision |
Low Hb deferral ‐ after multiple donation visits | RR 0.25 [0.15, 0.41] | 3 studies · 793 participants | Moderate Downgraded: risk of bias, imprecision |
Hb (g/L) ‐ before further donation Scale from: 123 to 152 | no estimate extracted | 8 studies · 847 participants | Moderate Downgraded: risk of bias, imprecision |
Hb (g/L) ‐ after subsequent donation(s) Scale from: 127.3 to 129 | no estimate extracted | 3 studies · 406 participants | Moderate Downgraded: risk of bias |
Serum ferritin (ng/mL) ‐ before further donation Scale from: 12.9 to 57.8 | no estimate extracted | 5 studies · 640 participants | Moderate Downgraded: risk of bias, imprecision |
Serum ferritin (ng/mL) ‐ after subsequent donation(s) Scale from: 18 to 19 | no estimate extracted | 3 studies · 619 participants | Moderate Downgraded: risk of bias, imprecision |
Adverse effects (any) | RR 1.6 [1.23, 2.07] | 4 studies · 1748 participants | Moderate Downgraded: risk of bias |