Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,155 questions · 1,191 findings · 195 reviews · Headline outcomes only

No studies found 209 · 17.5%GRADE not reported 51 · 4.3%Very low 256 · 21.5%Low 273 · 22.9%Moderate 284 · 23.8%High 118 · 9.9%

Twice daily or more vs once daily topical corticosteroid

Clinician‐reported signs of eczema: IGA (number with cleared or marked improvement); short term (earliest time point within 1‐4 weeks) · children and adults, most with moderate to severe eczema

Twice daily or more showed no clear difference in clinician‐reported signs of eczema: IGA (number with cleared or… compared with once daily topical corticosteroid (moderate certainty).

1 finding from 1 review

Twice daily or more vs once daily topical corticosteroid

Patient‐reported symptoms of eczema · children and adults, most with moderate to severe eczema

Twice daily or more showed no clear difference in patient‐reported symptoms of eczema: PGA (number with cleared or… compared with once daily topical corticosteroid (low certainty).

1 finding from 1 review

Ultrasound guidance vs landmark method

Patient satisfaction NRS from 0 to 10 or 4‐step Likert scale The higher the score, the higher the level of satisfaction · adults undergoing peripheral venous cannulation classed as moderately difficulta

The review found no eligible studies for this question.

1 finding from 1 review