Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

601 questions · 628 findings · 58 reviews

No studies found 131 · 20.9%GRADE not reported 92 · 14.6%Very low 167 · 26.6%Low 143 · 22.8%Moderate 76 · 12.1%High 19 · 3%

Antioxidants vs placebo

Global impression of deterioration (investigator defined global impression of deterioration) · people with multiple sclerosis

Antioxidant showed no clear difference in global impression of deterioration (investigator defined global… compared with placebo (low certainty).

1 finding from 1 review

Antioxidants vs placebo

Number of participants with gadolinium‐enhancing T1 lesions on MRI · people with multiple sclerosis

It is very uncertain whether antioxidant changes MRI activity(assessed as number of participants with… compared with placebo (very low certainty).

1 finding from 1 review

PUFA vs monounsaturated fatty acid (MUFA)

Global impression of deterioration (investigator defined global impression of deterioration) · people with multiple sclerosis

Polyunsaturated fatty acid (PUFA) showed no clear difference in global impression of deterioration (investigator defined global… compared with monounsaturated fatty acid (MUFA) (low certainty).

1 finding from 1 review