Findings

What do systematic reviews say?

873 questions · 883 findings · 38 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 319 · 36.1%GRADE not reported 18 · 2%Very low 198 · 22.4%Low 186 · 21.1%Moderate 147 · 16.6%High 15 · 1.7%

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Adherence · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Episodes of acute DIOS · adults and children with cystic fibrosis

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Adverse effects: abdominal mass · adults and children with cystic fibrosis

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Abdominal pain · adults and children with cystic fibrosis

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Summary of findings ‐ DVD plus information booklet vs information booklet alone

Mood or personal well‐being · adults and children with hemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ DVD plus information booklet vs information booklet alone

Coping strategies · adults and children with hemophilia

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 108 participants
Low

Summary of findings ‐ DVD plus information booklet vs information booklet alone

QoL · adults and children with hemophilia

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 108 participants
Low

Summary of findings ‐ DVD plus information booklet vs information booklet alone

Compliance or adherence to the trial intervention (including satisfaction): use of intervention at least once · adults and children with hemophilia

Summary of findings ‐ DVD plus information booklet showed no clear difference in compliance or adherence to the trial intervention (including… compared with information booklet alone (low certainty).

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
RR 1.02 [0.81, 1.28]
1 study · 108 participants
Low

Summary of findings ‐ DVD plus information booklet vs information booklet alone

Physical health: pain intensity (VAS post‐treatment scores) · adults and children with hemophilia

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 108 participants
Low

Summary of findings ‐ DVD plus information booklet vs information booklet alone

Cost of psychological intervention · adults and children with hemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ DVD plus information booklet vs information booklet alone

Family adjustment · adults and children with hemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings for airway clearance techniques vs no airway clearance techniques

FEV1 (% predicted): mean change from baseline · adults and children with cystic fibrosis

1 finding from 1 review

Airway clearance techniques compared to no airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 participants
GRADE not reported

Summary of findings for airway clearance techniques vs no airway clearance techniques

LCI · adults and children with cystic fibrosis

1 finding from 1 review

Airway clearance techniques compared to no airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 58 participants
Low

Summary of findings for airway clearance techniques vs no airway clearance techniques

Annual Exacerbation Rates · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Airway clearance techniques compared to no airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings for airway clearance techniques vs no airway clearance techniques

Mucus transport rate (radio tracer clearance) · adults and children with cystic fibrosis

1 finding from 1 review

Airway clearance techniques compared to no airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 55 participants
Very low

Summary of findings for airway clearance techniques vs no airway clearance techniques

Expectorated secretions (sputum wet weight) · adults and children with cystic fibrosis

1 finding from 1 review

Airway clearance techniques compared to no airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 47 participants
Very low

Summary of findings for airway clearance techniques vs no airway clearance techniques

Exercise capacity · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Airway clearance techniques compared to no airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings for airway clearance techniques vs no airway clearance techniques

Outcomes relevant to participants' well‐being · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Airway clearance techniques compared to no airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: inhaled TOBI® (IV preparation) vs tobramycin

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

1 finding from 1 review

Inhaled anti‐pseudomonal antibiotics for long‐term therapy in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Very low

Summary of findings: inhaled TOBI® (IV preparation) vs tobramycin

FVC (% predicted) Change from baseline · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

1 finding from 1 review

Inhaled anti‐pseudomonal antibiotics for long‐term therapy in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Very low