What do systematic reviews say?

Summary of findings table ‐ Open vs laparoscopic

Summary of findings table ‐ Open showed no clear difference in one year graft loss compared with laparoscopic (low certainty).

• Robotic versus laparoscopic versus open nephrectomy for live kidney donors 2024 · Cochrane Headline outcomes only
  RR 0.86 [0.25, 2.96]
  3 studies · 403 participants
  Low

Summary of findings table ‐ Open vs laparoscopic

• Robotic versus laparoscopic versus open nephrectomy for live kidney donors 2024 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 775 participants
  Moderate

Summary of findings table ‐ Open vs laparoscopic

It is very uncertain whether summary of findings table ‐ Open changes perioperative complications: pre 2010 compared with laparoscopic (very low certainty).

• Robotic versus laparoscopic versus open nephrectomy for live kidney donors 2024 · Cochrane Headline outcomes only
  RR 0.66 [0.39, 1.11]
  4 studies · 464 participants
  Very low

Summary of findings table ‐ Open vs laparoscopic

It is very uncertain whether summary of findings table ‐ Open changes perioperative complications: post 2010 compared with laparoscopic (very low certainty).

• Robotic versus laparoscopic versus open nephrectomy for live kidney donors 2024 · Cochrane Headline outcomes only
  RR 2.19 [1.53, 3.13]
  2 studies · 303 participants
  Very low

Summary of findings table ‐ Open vs laparoscopic

It is very uncertain whether summary of findings table ‐ Open changes perioperative complications: total compared with laparoscopic (very low certainty).

• Robotic versus laparoscopic versus open nephrectomy for live kidney donors 2024 · Cochrane Headline outcomes only
  RR 1.02 [0.55, 1.89]
  6 studies · 767 participants
  Very low

Summary of findings table ‐ Open vs laparoscopic

It is very uncertain whether summary of findings table ‐ Open changes reoperations compared with laparoscopic (very low certainty).

• Robotic versus laparoscopic versus open nephrectomy for live kidney donors 2024 · Cochrane Headline outcomes only
  RR 0.57 [0.09, 3.64]
  6 studies · 596 participants
  Very low

Summary of findings table ‐ Open vs laparoscopic

• Robotic versus laparoscopic versus open nephrectomy for live kidney donors 2024 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 815 participants
  Moderate

Summary of findings table ‐ Open vs laparoscopic

• Robotic versus laparoscopic versus open nephrectomy for live kidney donors 2024 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 775 participants
  Moderate

Summary of findings table ‐ ICSI vs c‐IVF

Summary of findings table ‐ ICSI showed no clear difference in live Birth compared with c‐IVF (low certainty).

• Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with… 2023 · Cochrane Headline outcomes only
  RR 1.11 [0.94, 1.3]
  2 studies · 1124 participants
  Low

Summary of findings table ‐ ICSI vs c‐IVF

Summary of findings table ‐ ICSI showed no clear difference in multiple Pregnancy compared with c‐IVF (moderate certainty).

• Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with… 2023 · Cochrane Headline outcomes only
  RR 0.89 [0.66, 1.2]
  2 studies · 1479 participants
  Moderate

Summary of findings table ‐ ICSI vs c‐IVF

Summary of findings table ‐ ICSI showed no clear difference in ectopic Pregnancy compared with c‐IVF (moderate certainty).

• Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with… 2023 · Cochrane Headline outcomes only
  RR 1 [0.42, 2.38]
  1 study · 1064 participants
  Moderate

Summary of findings table ‐ ICSI vs c‐IVF

Summary of findings table ‐ ICSI showed no clear difference in pre‐Eclampsia compared with c‐IVF (moderate certainty).

• Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with… 2023 · Cochrane Headline outcomes only
  RR 1 [0.06, 15.95]
  1 study · 1064 participants
  Moderate

Summary of findings table ‐ ICSI vs c‐IVF

Summary of findings table ‐ ICSI showed no clear difference in prematurity compared with c‐IVF (moderate certainty).

• Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with… 2023 · Cochrane Headline outcomes only
  RR 0.75 [0.53, 1.06]
  1 study · 1064 participants
  Moderate

Summary of findings table ‐ ICSI vs c‐IVF

Summary of findings table ‐ ICSI showed no clear difference in clinical Pregnancy compared with c‐IVF (low certainty).

• Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with… 2023 · Cochrane Headline outcomes only
  RR 1 [0.88, 1.13]
  3 studies · 1539 participants
  Low

Summary of findings table ‐ ICSI vs c‐IVF

Summary of findings table ‐ ICSI showed no clear difference in viable intrauterine Pregnancy compared with c‐IVF (moderate certainty).

• Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with… 2023 · Cochrane Headline outcomes only
  RR 1 [0.86, 1.16]
  2 studies · 1479 participants
  Moderate

Summary of findings table ‐ ICSI vs c‐IVF

Summary of findings table ‐ ICSI showed no clear difference in miscarriage compared with c‐IVF (moderate certainty).

• Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with… 2023 · Cochrane Headline outcomes only
  RR 0.96 [0.58, 1.61]
  1 study · 1064 participants
  Moderate

Lamotrigine vs placebo

Summary of findings: lamotrigine probably leads to higher 50% or greater reduction in seizure frequency (ITT analysis) compared with placebo (moderate certainty).

• Lamotrigine add‐on therapy for drug‐resistant focal epilepsy 2023 · Cochrane Headline outcomes only
  RR 1.8 [1.45, 2.23]
  12 studies · 1322 participants
  Moderate

Lamotrigine vs placebo

Summary of findings: lamotrigine showed no clear difference in treatment withdrawal compared with placebo (moderate certainty).

• Lamotrigine add‐on therapy for drug‐resistant focal epilepsy 2023 · Cochrane Headline outcomes only
  RR 1.11 [0.91, 1.37]
  14 studies · 1806 participants
  Moderate

Lamotrigine vs placebo

Summary of findings: lamotrigine probably leads to higher ataxia compared with placebo (moderate certainty).

• Lamotrigine add‐on therapy for drug‐resistant focal epilepsy 2023 · Cochrane Headline outcomes only
  RR 3.34
  12 studies · 1525 participants
  Moderate

Lamotrigine vs placebo

Summary of findings: lamotrigine probably leads to higher dizziness compared with placebo (moderate certainty).

• Lamotrigine add‐on therapy for drug‐resistant focal epilepsy 2023 · Cochrane Headline outcomes only
  RR 1.76
  13 studies · 1768 participants
  Moderate