Oral health-related quality of life · Children with dental caries
SDF did not significantly differ from placebo for oral health-related quality of life in children (MD 0.03, 95% CI -0.16 to 0.22; ungraded).
1 finding from 1 review
Oral health-related quality of life · Children with dental caries
The direct estimate found no statistically significant difference in oral health-related quality of life between atraumatic restorative treatment plus fluoride varnish and silver diamine fluoride plus fluoride varnish.
2 findings from 1 review
Oral health-related quality of life · Children with dental caries
SDF did not significantly differ from atraumatic restorative treatment for oral health-related quality of life (MD 0.02, 95% CI -0.32 to 0.36; ungraded).
1 finding from 1 review
Recurrent oral ulceration prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in recurrent oral ulceration between ART regimens (very low certainty).
1 finding from 1 review
HIV-related oral lesions · Children and adolescents living with HIV on ART/HAART
Lower CD4+ counts (<250 cells/mm3) were associated with roughly twice the odds of HIV-related oral lesions in two studies (not pooled).
1 finding from 1 review
Oral Health Status of Children and Adolescents Living with HIV Undergoing Antiretroviral Therapy: A Systematic Review… 2022 All outcomesCross-sectional (case-control; single time point) · HIV pediatric/ART clinics, AIDS centers, and hospitals in Brazil, India, Saudi Arabia, and West Africa (Cote d'Ivoire, Mali, Senegal) · CD4+ T-cell count <250 cells/mm3 vs higher
CLWH with CD4+ <250 cells/mm3 were about twice as likely to have HIV-related oral lesions: Baghirath 2013 OR 1.916 (95% CI 0.613 to 2.513), p=0.001; Divakar 2015 OR 1.999 (95% CI 0.129 to 3.688), p=0.001. Not pooled.
2 studies
GRADE not reported
Oral health-related quality of life · Children with dental caries
The network estimate found no statistically significant difference in oral health-related quality of life between atraumatic restorative treatment and silver diamine fluoride.
2 findings from 1 review
Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
cART was associated with a significantly lower prevalence of oral candidiasis in CLWH (very low certainty).
1 finding from 1 review
OR 0.35 [0.24, 0.51]
Studies not reported
Very low
Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Oral candidiasis prevalence did not differ significantly between treatment-naive CLWH and those on monotherapy or dual therapy (very low certainty).
1 finding from 1 review
Poor (inadequate) oral hygiene (prevalence) · Children or adolescents
No significant difference in oral hygiene between CLWH on ART and healthy controls (OR 1.23, 95% CI 0.73 to 2.07; single study).
1 finding from 1 review
Oral health-related quality of life · Children with dental caries
SDF plus fluoride varnish did not significantly differ from ART plus fluoride varnish for oral health-related quality of life (MD 0.16, 95% CI -0.1 to 0.42; ungraded).
1 finding from 1 review
Oral candidiasis · Children and adolescents living with HIV on ART/HAART
Oral candidiasis prevalence differed by ART duration (OR 17.93, 95% CI 3.69 to 83.12).
1 finding from 1 review
Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
ART was associated with lower oral candidiasis prevalence.
1 finding from 1 review
OR 0.35 [0.19, 0.63]
7 studies
Very low
Recurrent oral ulceration prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in recurrent oral ulceration between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 1.50 [0.72, 3.13]
Studies not reported
Very low
Oral hairy leukoplakia prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in oral hairy leukoplakia between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 2.75 [0.39, 19.43]
Studies not reported
Very low
Proportion of children with other untreated oral health needs · School children (aged 4 to 15 years), primary and secondary schools in the UK and India
The review found no eligible studies for this question.
1 finding from 1 review
Oral hairy leukoplakia (WHO clinical stage 3) · Children or adolescents
No difference in oral hairy leukoplakia between groups (pooled OR 1.00, 95% CI 0.06 to 16.19); lesion essentially absent in both.
1 finding from 1 review
Oral candidiasis (WHO clinical stage 3) · Children or adolescents
CLWH on ART had markedly higher prevalence of oral candidiasis than healthy controls (pooled OR 16.94, 95% CI 5.06 to 56.70).
1 finding from 1 review
Oral hairy leukoplakia prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No eligible studies compared oral hairy leukoplakia between different ART regimens.
1 finding from 1 review
Oral health-related quality of life · Children with dental caries
SDF had no significant effect on oral health-related quality of life versus pooled standard-of-care caries treatments (SMD -0.06, 95% CI -0.20 to 0.08; ungraded).
1 finding from 1 review
Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
cART was associated with a significantly lower prevalence of oral candidiasis than monotherapy or dual therapy (very low certainty).
1 finding from 1 review
OR 0.22 [0.16, 0.29]
4 studies
Very low