Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,805 questions · 2,912 findings · 307 reviews · Headline outcomes only

No studies found 706 · 24.2%GRADE not reported 133 · 4.6%Very low 786 · 27%Low 696 · 23.9%Moderate 474 · 16.3%High 117 · 4%

Intervention not reported

Child cognitive ability As assessed by the Griffith Mental Development scale at 18‐month · children younger than five years of age and their families

It is very uncertain whether the intervention changes child cognitive ability As assessed by the Griffith Mental… (very low certainty).

1 finding from 1 review

Intervention not reported

Child psychosocial development Parents reporting their child develops abnormally · children younger than five years of age and their families

It is very uncertain whether the intervention changes child psychosocial development Parents reporting their child… (very low certainty).

1 finding from 1 review

Intervention not reported

Paid maternal employment Mothers in full‐time or part‐time employment · children younger than five years of age and their families

It is very uncertain whether the intervention changes paid maternal employment Mothers in full‐time or part‐time employment (very low certainty).

1 finding from 1 review

Intervention not reported

Paid maternal employment Maternal hours per week in paid employment · children younger than five years of age and their families

It is very uncertain whether the intervention changes paid maternal employment Maternal hours per week in paid employment (very low certainty).

1 finding from 1 review

Intervention not reported

Household income Households with weekly income > £200 · children younger than five years of age and their families

It is very uncertain whether the intervention changes household income Households with weekly income > £200 (very low certainty).

1 finding from 1 review

Intervention not reported

Quality of life1 Paediatric Asthma Quality of Life Questionnaire (PAQLQ). Scale from: 1 (worse) to 7 (better). · children and adolescents aged 18 years and under studies with asthma
1 finding from 1 review

Intervention not reported

Exacerbations requiring a course of oral corticosteroids · children and adolescents aged 18 years and under studies with asthma

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Urgent asthma physician visits1 Number of times the child visited a physician's office/clinic for an asthma flare up · children and adolescents aged 18 years and under studies with asthma
1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Death · HIV‐positive, treatment‐naive children aged one to 12 years old

It is very uncertain whether IMMEDIATE initiation of cART changes death compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category C disease (number of children) · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes CDC Category C disease (number of children) compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category B disease (numbers of children) Peto Odds Ratio · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes CDC Category B disease (numbers of children) Peto Odds Ratio compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Proportion of children on ART with HIV‐RNA < 50 copies/ml · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes proportion of children on ART with HIV‐RNA < 50 copies/ml compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category C disease (number of children) · HIV‐positive, treatment‐naive children aged one to 12 years old

It is very uncertain whether IMMEDIATE initiation of cART changes CDC Category C disease (number of children) compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review