Findings

What do systematic reviews say?

747 questions · 815 findings · 144 reviews

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No studies found 154 · 18.9%GRADE not reported 147 · 18%Very low 164 · 20.1%Low 199 · 24.4%Moderate 121 · 14.8%High 30 · 3.7%

Intervention not reported

Differences in quality of life ( · adults presenting with elevated intracranial pressure secondary to a traumatic brain injury

1 finding from 1 review

Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Low polymerization shrinkage resin composite (silorane, ormocer, bulk-fill or other modified-monomer composite) vs Conventional methacrylate-based resin composite

Marginal adaptation (clinically detectable deterioration) · People with permanent posterior teeth restored with class I or II direct restorations

At 60 months, marginal adaptation did not differ significantly between the composites (4 groups; ungraded).

5 findings from 1 review

Meta-analysis of the clinical behavior of posterior direct resin restorations: Low polymerization shrinkage resin in… 2018 All outcomes
60 months · Posterior class I/II restorations in permanent teeth; multicenter randomized controlled trials conducted across Europe, the Americas, and the Middle East
Three articles (four experimental groups) evaluated marginal adaptation after 60 months; two favored the experimental group but the overall meta-analytic effect was not statistically significant.
3 studies
GRADE not reported
Meta-analysis of the clinical behavior of posterior direct resin restorations: Low polymerization shrinkage resin in… 2018 All outcomes
36 months · Posterior class I/II restorations in permanent teeth; multicenter randomized controlled trials conducted across Europe, the Americas, and the Middle East
Five articles (six experimental groups) evaluated marginal adaptation after 36 months; results were mixed and the overall meta-analytic effect was not statistically significant.
5 studies
GRADE not reported
Meta-analysis of the clinical behavior of posterior direct resin restorations: Low polymerization shrinkage resin in… 2018 All outcomes
18 months · Posterior class I/II restorations in permanent teeth; multicenter randomized controlled trials conducted across Europe, the Americas, and the Middle East
Only two studies, both testing silorane composites, evaluated marginal adaptation after 18 months; one favored the experimental group and one the control group, and the overall meta-analytic effect was not…
2 studies
GRADE not reported

Show 2 more findings

Meta-analysis of the clinical behavior of posterior direct resin restorations: Low polymerization shrinkage resin in… 2018 All outcomes
12 months · Posterior class I/II restorations in permanent teeth; multicenter randomized controlled trials conducted across Europe, the Americas, and the Middle East
OR 1.77 [1.25, 2.50]
15 studies · 2280 participants
GRADE not reported
Meta-analysis of the clinical behavior of posterior direct resin restorations: Low polymerization shrinkage resin in… 2018 All outcomes
24 months · Posterior class I/II restorations in permanent teeth; multicenter randomized controlled trials conducted across Europe, the Americas, and the Middle East
Odds ratio (OR) 1.46 [0.92, 2.33]
7 studies
GRADE not reported

Low polymerization shrinkage resin composite (silorane, ormocer, bulk-fill or other modified-monomer composite) vs Conventional methacrylate-based resin composite

Secondary caries · People with permanent posterior teeth restored with class I or II direct restorations

No secondary caries was reported at 24 months in any of seven studies, so no meta-analysis was possible (ungraded).

2 findings from 1 review

Meta-analysis of the clinical behavior of posterior direct resin restorations: Low polymerization shrinkage resin in… 2018 All outcomes
24 months · Posterior class I/II restorations in permanent teeth; multicenter randomized controlled trials conducted across Europe, the Americas, and the Middle East
After 24 months, seven articles evaluated secondary caries, but none reported any secondary caries in either group; a meta-analysis was therefore not conducted.
7 studies
GRADE not reported
Meta-analysis of the clinical behavior of posterior direct resin restorations: Low polymerization shrinkage resin in… 2018 All outcomes
12 months · Posterior class I/II restorations in permanent teeth; multicenter randomized controlled trials conducted across Europe, the Americas, and the Middle East
OR 1.51 [0.64, 3.57]
14 studies · 2087 participants
GRADE not reported

Low polymerization shrinkage resin composite (silorane, ormocer, bulk-fill or other modified-monomer composite) vs Conventional methacrylate-based resin composite

Marginal discoloration · People with permanent posterior teeth restored with class I or II direct restorations

At 24 months, marginal discoloration did not differ significantly (7 groups; p = 0.77; ungraded).

4 findings from 1 review

Meta-analysis of the clinical behavior of posterior direct resin restorations: Low polymerization shrinkage resin in… 2018 All outcomes
24 months · Posterior class I/II restorations in permanent teeth; multicenter randomized controlled trials conducted across Europe, the Americas, and the Middle East
Odds ratio (OR) 1.08 [0.64, 1.84]
6 studies
GRADE not reported
Meta-analysis of the clinical behavior of posterior direct resin restorations: Low polymerization shrinkage resin in… 2018 All outcomes
60 months · Posterior class I/II restorations in permanent teeth; multicenter randomized controlled trials conducted across Europe, the Americas, and the Middle East
Two articles (three experimental groups) evaluated marginal discoloration after 60 months; the meta-analysis showed no difference in the overall effect.
2 studies
GRADE not reported
Meta-analysis of the clinical behavior of posterior direct resin restorations: Low polymerization shrinkage resin in… 2018 All outcomes
12 months · Posterior class I/II restorations in permanent teeth; multicenter randomized controlled trials conducted across Europe, the Americas, and the Middle East
OR 1.53 [0.98, 2.41]
13 studies · 2082 participants
GRADE not reported

Show 1 more finding

Meta-analysis of the clinical behavior of posterior direct resin restorations: Low polymerization shrinkage resin in… 2018 All outcomes
18 months · Posterior class I/II restorations in permanent teeth; multicenter randomized controlled trials conducted across Europe, the Americas, and the Middle East
Only two articles, both testing silorane resins, evaluated marginal discoloration after 18 months; one favored the experimental group and one the control group, with the meta-analysis showing no difference in the…
2 studies
GRADE not reported

Low polymerization shrinkage resin composite (silorane, ormocer, bulk-fill or other modified-monomer composite) vs Conventional methacrylate-based resin composite

Retention (restoration loss) · People with permanent posterior teeth restored with class I or II direct restorations

At 24 months, retention did not differ significantly between the composites (6 studies; ungraded).

2 findings from 1 review

Meta-analysis of the clinical behavior of posterior direct resin restorations: Low polymerization shrinkage resin in… 2018 All outcomes
24 months · Posterior class I/II restorations in permanent teeth; multicenter randomized controlled trials conducted across Europe, the Americas, and the Middle East
Six articles assessed restoration retention after 24 months; four showed no loss of retention in either group and two favored the control group, with no difference in the overall meta-analytic effect.
6 studies
GRADE not reported
Meta-analysis of the clinical behavior of posterior direct resin restorations: Low polymerization shrinkage resin in… 2018 All outcomes
12 months · Posterior class I/II restorations in permanent teeth; multicenter randomized controlled trials conducted across Europe, the Americas, and the Middle East
OR 0.83 [0.33, 2.09]
11 studies · 1834 participants
GRADE not reported

Low polymerization shrinkage resin composite (silorane, ormocer, bulk-fill or other modified-monomer composite) vs Conventional methacrylate-based resin composite

Postoperative sensitivity · People with permanent posterior teeth restored with class I or II direct restorations

Postoperative sensitivity at 12 months did not differ significantly between low polymerization shrinkage and methacrylate composites (OR 1.65, 95% CI 0.71 to 3.81; Moderate certainty).

2 findings from 1 review

Meta-analysis of the clinical behavior of posterior direct resin restorations: Low polymerization shrinkage resin in… 2018 All outcomes
12 months · Posterior class I/II restorations in permanent teeth; multicenter randomized controlled trials conducted across Europe, the Americas, and the Middle East
OR 1.65 [0.71, 3.81]
10 studies · 970 participants
GRADE not reported
Meta-analysis of the clinical behavior of posterior direct resin restorations: Low polymerization shrinkage resin in… 2018 All outcomes
24 months · Posterior class I/II restorations in permanent teeth; multicenter randomized controlled trials conducted across Europe, the Americas, and the Middle East
Six articles (seven experimental groups) evaluated postoperative sensitivity after 24 months; four showed no sensitivity in either group and three favored the control group, but the overall meta-analytic effect was not…
6 studies
GRADE not reported

Intervention not reported

Subjective success (i.e. resolution of symptoms of watering following surgery) · People with nasolacrimal duct obstruction

1 finding from 1 review

Endonasal versus external dacryocystorhinostomy for nasolacrimal duct obstruction 2017 · Cochrane Headline outcomes only
no estimate extracted
5 participants
Low

Intervention not reported

Intraoperative bleeding · People with nasolacrimal duct obstruction

1 finding from 1 review

Endonasal versus external dacryocystorhinostomy for nasolacrimal duct obstruction 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Postoperative bleeding · People with nasolacrimal duct obstruction

It is very uncertain whether the intervention changes postoperative bleeding (very low certainty).

1 finding from 1 review

Endonasal versus external dacryocystorhinostomy for nasolacrimal duct obstruction 2017 · Cochrane Headline outcomes only
RR 0.33 [0.04, 3.1]
2 studies · 104 participants
Very low

Intervention not reported

Wound infection/gaping · People with nasolacrimal duct obstruction

1 finding from 1 review

Endonasal versus external dacryocystorhinostomy for nasolacrimal duct obstruction 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Treatment success (at 6 months) · children with congenital nasolacrimal duct obstruction (NLDO)

1 finding from 1 review

Probing for congenital nasolacrimal duct obstruction 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Intervention not reported

Treatment success (at other time points) · children with congenital nasolacrimal duct obstruction (NLDO)

It is very uncertain whether the intervention changes treatment success (at other time points) (very low certainty).

1 finding from 1 review

Probing for congenital nasolacrimal duct obstruction 2017 · Cochrane Headline outcomes only
RR 1.13 [0.99, 1.28]
1 study · 146 participants
Very low

Intervention not reported

Proportion of participants requiring secondary procedures · children with congenital nasolacrimal duct obstruction (NLDO)

The review found no eligible studies for this question.

1 finding from 1 review

Probing for congenital nasolacrimal duct obstruction 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Cost‐effectiveness · children with congenital nasolacrimal duct obstruction (NLDO)

1 finding from 1 review

Probing for congenital nasolacrimal duct obstruction 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 163 participants
Moderate

Intervention not reported

Complications · children with congenital nasolacrimal duct obstruction (NLDO)

The review found no eligible studies for this question.

1 finding from 1 review

Probing for congenital nasolacrimal duct obstruction 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Death or dependency in ADL 3 months post‐operatively · people with intracranial aneurysm

1 finding from 1 review

Intraoperative mild hypothermia for postoperative neurological deficits in people with intracranial aneurysm 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1164 participants
Moderate

Intervention not reported

Newly developed postsurgical vasospasm or infarction during hospitalisation · people with intracranial aneurysm

1 finding from 1 review

Intraoperative mild hypothermia for postoperative neurological deficits in people with intracranial aneurysm 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1164 participants
GRADE not reported

Intervention not reported

Duration of hospitalisation · people with intracranial aneurysm

1 finding from 1 review

Intraoperative mild hypothermia for postoperative neurological deficits in people with intracranial aneurysm 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 114 participants
GRADE not reported

Intervention not reported

Destination of discharge (home or to another hospital) · people with intracranial aneurysm

1 finding from 1 review

Intraoperative mild hypothermia for postoperative neurological deficits in people with intracranial aneurysm 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 114 participants
GRADE not reported

Intervention not reported

Postoperative infection of the wound, the lung, the urinary tract, or the skin within one week after surgery · people with intracranial aneurysm

1 finding from 1 review

Intraoperative mild hypothermia for postoperative neurological deficits in people with intracranial aneurysm 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1164 participants
GRADE not reported