Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,340 questions · 1,512 findings · 205 reviews

No studies found 317 · 21%GRADE not reported 358 · 23.7%Very low 356 · 23.5%Low 271 · 17.9%Moderate 173 · 11.4%High 37 · 2.4%

Stabilisation splint (SS) vs Non-occluding splint

Movement (increase in maximal mouth opening) · Patients with pain dysfunction syndrome (PDS) of all degrees of severity

Stabilisation splint (SS) showed no clear difference in movement (increase in maximal mouth opening) compared with non-occluding splint; GRADE not reported.

1 finding from 1 review

Stabilisation splint (SS) vs relaxation

Maximal mouth opening (interincisal distance) · Patients with pain dysfunction syndrome (PDS) of all degrees of severity
1 finding from 1 review

Negative pressure wound therapy vs conventional open wound healing

Time to complete healing · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

It is very uncertain whether topical negative pressure wound therapy changes time to wound healing (days) compared with conventional open wound healing (very low certainty).

1 finding from 1 review

Negative pressure wound therapy vs conventional open wound healing

Proportion of wounds healed · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

It is very uncertain whether topical negative pressure wound therapy changes proportion of wounds healed at 30 days compared with conventional open wound healing (very low certainty).

3 findings from 1 review

Negative pressure wound therapy vs conventional open wound healing

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

The review found no eligible studies for this question.

1 finding from 1 review

Early discontinuation of antibiotic treatment vs treatment until neutropenia resolution

All‐cause mortality · febrile neutropenia

Early discontinuation of antibiotic treatment showed no clear difference in mortality compared with treatment until neutropenia resolution (low certainty).

1 finding from 1 review

Early discontinuation of antibiotic treatment vs treatment until neutropenia resolution

Clinical failure · febrile neutropenia

It is very uncertain whether early discontinuation of antibiotic treatment changes clinical failure compared with treatment until neutropenia resolution (very low certainty).

1 finding from 1 review

Early discontinuation of antibiotic treatment vs treatment until neutropenia resolution

Bacteraemia · febrile neutropenia

It is very uncertain whether early discontinuation of antibiotic treatment changes any bacteraemia compared with treatment until neutropenia resolution (very low certainty).

1 finding from 1 review

Drainage vs no drainage after open appendectomy

Intraperitoneal abscess · people undergoing emergency open appendectomy for complicated appendicitis

It is very uncertain whether drainage changes intraperitoneal abscess compared with no drainage after open appendectomy (very low certainty).

1 finding from 1 review