Findings

What do systematic reviews say?

521 questions · 544 findings · 62 reviews

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No studies found 153 · 28.1%GRADE not reported 29 · 5.3%Very low 134 · 24.6%Low 123 · 22.6%Moderate 80 · 14.7%High 25 · 4.6%

Misoprostol vs surgery

Diarrhoea · incomplete miscarriage

Misoprostol probably leads to higher diarrhoea compared with surgery (moderate certainty).

1 finding from 1 review

Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
RR 4.82 [1.09, 21.32]
4 studies · 757 participants
Moderate

Misoprostol vs expectant care

Surgical evacuation · incomplete miscarriage

Misoprostol showed no clear difference in surgical evacuation compared with expectant care (low certainty).

1 finding from 1 review

Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
RR 0.62 [0.17, 2.26]
2 studies · 308 participants
Low

Misoprostol vs expectant care

Unplanned surgical intervention · incomplete miscarriage

Misoprostol showed no clear difference in unplanned surgical intervention compared with expectant care (low certainty).

1 finding from 1 review

Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
RR 0.62 [0.17, 2.26]
2 studies · 308 participants
Low

Misoprostol vs expectant care

Women's views/acceptability of method · incomplete miscarriage

1 finding from 1 review

Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Misoprostol vs expectant care

Nausea · incomplete miscarriage

1 finding from 1 review

Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Misoprostol vs expectant care

Vomiting · incomplete miscarriage

1 finding from 1 review

Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Misoprostol vs expectant care

Diarrhoea · incomplete miscarriage

1 finding from 1 review

Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Misoprostol vs surgery

Complete miscarriage · incomplete miscarriage

It is very uncertain whether misoprostol changes complete miscarriage compared with surgery (very low certainty).

1 finding from 1 review

Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
RR 0.96 [0.94, 0.98]
15 studies · 3862 participants
Very low

Misoprostol vs surgery

Surgical evacuation · incomplete miscarriage

It is very uncertain whether misoprostol changes surgical evacuation compared with surgery (very low certainty).

1 finding from 1 review

Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
RR 0.05 [0.02, 0.11]
13 studies · 3070 participants
Very low

Imiquimod vs cidofovir

Pain ‐ Any grade · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod showed no clear difference in pain ‐ any grade compared with cidofovir (moderate certainty).

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
RR 1.16 [0.92, 1.47]
1 study · 168 participants
Moderate

Imiquimod vs cidofovir

Fatigue · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod probably leads to higher fatigue ‐ any grade compared with cidofovir (moderate certainty).

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
RR 1.25 [1.02, 1.55]
1 study · 168 participants
Moderate

Imiquimod vs cidofovir

Headache · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod probably leads to higher headache ‐ any grade compared with cidofovir (moderate certainty).

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
RR 1.49 [1.12, 1.98]
1 study · 168 participants
Moderate

Imiquimod vs cidofovir

Total serious adverse events · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod showed no clear difference in total serious adverse events compared with cidofovir (moderate certainty).

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
RR 1.26 [0.88, 1.81]
1 study · 168 participants
Moderate

Intervention not reported

Surgical excision versus laser vaporisationor other · women with usual‐type vulval intraepithelial neoplasia

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 73 participants
Low

Intervention not reported

Laser vaporisation versus CUSA · women with usual‐type vulval intraepithelial neoplasia

The intervention showed no clear difference in laser vaporisation versus CUSA (low certainty).

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
RR 1.53 [0.56, 4.15]
1 study · 30 participants
Low

Intervention not reported

Photodynamic therapy versus laser vaporisationand surgical excision · women with usual‐type vulval intraepithelial neoplasia

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 52 participants
Very low

Intervention not reported

LEEP versus laser vaporisation and surgical excision · women with usual‐type vulval intraepithelial neoplasia

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Very low

Imiquimod vs placebo

Progression to vulval cancer at 12 months · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod showed no clear difference in progression to vulval cancer at 12 months compared with placebo (low certainty).

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
RR 0.48 [0.05, 4.93]
1 study · 47 participants
Low

Imiquimod vs placebo

HPV DNA persistence · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod leads to lower HPV DNA persistence compared with placebo (high certainty).

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
RR 0.43 [0.26, 0.72]
1 study · 47 participants
High

Imiquimod vs placebo

Pain ‐ Any grade · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod leads to higher pain ‐ any grade compared with placebo (high certainty).

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
RR 3.43 [1.8, 6.52]
1 study · 52 participants
High