Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,361 questions · 1,518 findings · 352 reviews

No studies found 73 · 4.8%GRADE not reported 211 · 13.9%Very low 500 · 32.9%Low 411 · 27.1%Moderate 252 · 16.6%High 71 · 4.7%

Methotrexate vs mycophenolate

Proportion of participants achieving control of inflammation (higher number of events is better) · NIIPPU

Methotrexate probably leads to higher proportion of participants achieving control of inflammation§… compared with mycophenolate (moderate certainty).

1 finding from 1 review

Maternal education attainment vs Not applicable (single-group prevalence)

Secondary/higher maternal education prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries

About 45% of children with caries in LMICs had mothers with secondary or higher education (pooled prevalence 0.450, 95% CI 0.330 to 0.572; 7 studies; not GRADE-rated).

1 finding from 1 review

n3PUFAs vs placebo

Depressive symptomology (continuous) HDRS where possible; higher scores indicate greater symptomology · adults with Major Depressive Disorder
1 finding from 1 review

n3PUFAs vs placebo

Quality of lifeValidated quality of life scales as used by authors, CGI (7‐point scale) where possible, higher scores indicate poorer quality of life · adults with Major Depressive Disorder
1 finding from 1 review

Supported discharge and multidisciplinary home rehabilitation vs (Optimised) usual care

'Poor outcome' (dead or moved to higher level of care or unable to walk) · Older people undergoing hip fracture aftercare

It is very uncertain whether supported discharge and multidisciplinary home rehabilitation changes 'Poor outcome' (dead or moved to higher level of care or unable to… compared with usual care: mainly (very low certainty).

1 finding from 1 review

Supported discharge and multidisciplinary home rehabilitation vs (Optimised) usual care

Permanent move to higher level of care (hostel, nursing home, sheltered housing) · Older people undergoing hip fracture aftercare

It is very uncertain whether supported discharge and multidisciplinary home rehabilitation changes permanent move to higher level of care (hostel, nursing home,… compared with usual care: mainly (very low certainty).

1 finding from 1 review