Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,006 questions · 3,171 findings · 607 reviews · Headline outcomes only

No studies found 411 · 13%GRADE not reported 153 · 4.8%Very low 968 · 30.5%Low 897 · 28.3%Moderate 589 · 18.6%High 153 · 4.8%

Vitamin D (higher dose) vs vitamin D (lower dose)

Adverse effect: hypercalciuria As defined by trialists Time frame: 3 months · children under 5 years of age

Vitamin D (higher dose) showed no clear difference in adverse effect: hypercalciuria As defined by trialists Time frame:… compared with vitamin D (lower dose) (low certainty).

1 finding from 1 review

Vitamin D (higher dose) vs vitamin D (lower dose)

Hypercalcaemia · children under 5 years of age

Vitamin D (higher dose) showed no clear difference in adverse effect: hypercalcaemia As defined by trialists Time frame:… compared with vitamin D (lower dose) (low certainty).

1 finding from 1 review

High frequency ultrasound vs no ultrasound

Ulcers completely healed · people with venous leg ulcers

It is very uncertain whether high frequency ultrasound changes proportion of ulcers completely healed at 3 weeks compared with no ultrasound (very low certainty).

3 findings from 1 review