Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

643 questions · 693 findings · 156 reviews

No studies found 177 · 25.5%GRADE not reported 100 · 14.4%Very low 144 · 20.8%Low 139 · 20.1%Moderate 106 · 15.3%High 27 · 3.9%

COMPARISON 1. ARIPIPRAZOLE vs placebo

Requirement for anticholinergics number of participants requiring medication for extrapyramidal side effects · patients with an acute manic or mixed episode

Aripiprazole leads to higher requirement for anticholinergics number of participants requiring… compared with placebo (high certainty).

1 finding from 1 review

Any Psychosocial intervention plus pharm vs pharm standard

Retention in treatment · patients with treatment of opioid dependence

Any Psychosocial intervention plus pharm showed no clear difference in retention in treatment Objective compared with pharm standard (high certainty).

1 finding from 1 review

Any Psychosocial intervention plus pharm vs pharm standard

Opioid abstinence objective · patients with treatment of opioid dependence

Any Psychosocial intervention plus pharm showed no clear difference in opioid abstinence objective compared with pharm standard (high certainty).

1 finding from 1 review

NBI + WLC TURBT vs WLC TURBT

Time to recurrence · transurethral resection of bladder tumors in people with suspected or diagnosed non‐muscle invasive bladder cancer

NBI + WLC TURBT may leads to lower time to disease recurrence compared with WLC TURBT (low certainty).

1 finding from 1 review

NBI + WLC TURBT vs WLC TURBT

Clavien‐Dindo grade ≥ 3 complications · transurethral resection of bladder tumors in people with suspected or diagnosed non‐muscle invasive bladder cancer

NBI + WLC TURBT showed no clear difference in major adverse event (Clavien‐Dindo grade III, IV, and V) compared with WLC TURBT (low certainty).

1 finding from 1 review

NBI + WLC TURBT vs WLC TURBT

Clavien‐Dindo grade ≤ 2 complications8 · transurethral resection of bladder tumors in people with suspected or diagnosed non‐muscle invasive bladder cancer

NBI + WLC TURBT showed no clear difference in minor adverse event (Clavien‐Dindo grade I and II) compared with WLC TURBT (low certainty).

1 finding from 1 review

IRI with fluoropyrimidines vs single agent IRI

Progression‐free survival (PSF) · patients with advanced and/or metastatic colorectal cancer

IRI with fluoropyrimidines probably leads to lower progression‐free survival (Disease progression) compared with single agent IRI (moderate certainty).

1 finding from 1 review

Intervention not reported

Lymph node mets analysis ‐ N+ OS · patients with resectable gastric cancer

The intervention probably leads to lower lymph node mets analysis ‐ N+ OS (moderate certainty).

1 finding from 1 review

Intervention not reported

Chemobased OS ‐ 5‐FU based chemotherapy OS · patients with resectable gastric cancer

The intervention probably leads to lower chemobased OS ‐ 5‐FU based chemotherapy OS (moderate certainty).

1 finding from 1 review