Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,543 questions · 2,589 findings · 168 reviews · Schizophrenia

No studies found 601 · 23.2%GRADE not reported 446 · 17.2%Very low 721 · 27.8%Low 505 · 19.5%Moderate 274 · 10.6%High 42 · 1.6%

Benzodiazepines vs placebo

Acceptability · patients with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether benzodiazepines changes acceptability of the treatment (measured by participants leaving the… compared with placebo (very low certainty).

1 finding from 1 review

Benzodiazepines vs phenobarbital (as active placebo)

Tardive dyskinesia: No clinically important improvement · patients with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether benzodiazepines changes tardive dyskinesia: no clinically important improvement compared with phenobarbital (as active placebo) (very low certainty).

1 finding from 1 review

Intervention not reported

Tardive dyskinesia ‐ not improved to a clinically important extent · people with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether the intervention changes tardive dyskinesia ‐ not improved to a clinically important extent (very low certainty).

1 finding from 1 review

Intervention not reported

Tardive dyskinesia ‐ deterioration · people with antipsychotic‐induced tardive dyskinesia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse effects ‐ important extrapyramidal adverse effects · people with antipsychotic‐induced tardive dyskinesia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Acceptability of treatment ‐ leaving the study early · people with antipsychotic‐induced tardive dyskinesia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Social confidence, social inclusion, social networks or personalised quality of life measures ‐ no clinically significant change · people with antipsychotic‐induced tardive dyskinesia

The review found no eligible studies for this question.

1 finding from 1 review

CHOLINERGIC DRUGS vs placebo

Tardive dyskinesia: No clinically important improvement · patients with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether CHOLINERGIC DRUGS changes tardive dyskinesia: No clinically important improvement compared with PLACEBO (very low certainty).

1 finding from 1 review