Cochrane · systematic review · CD000207
Cholinergic medication for antipsychotic‐induced tardive dyskinesia
Tammenmaa‐Aho, I, Asher, R, Soares‐Weiser, K, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
1
Included studies
NR
No studies 1 · 16.7%Ungraded 0 · 0%Very low 4 · 66.7%Low 1 · 16.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
CHOLINERGIC DRUGS versus PLACEBO for antipsychotic‐induced tardive dyskinesia
Population: people with various psychiatric disorders (mainly schizophrenia) and antipsychotic‐induced tardive dyskinesia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Tardive dyskinesia: No clinically important improvement CHOLINERGIC DRUGS vs PLACEBO | RR 0.89 [0.65, 1.23] | 4 studies · 27 participants | Very low Downgraded: risk of bias, imprecision |
Tardive dyskinesia: Deterioration CHOLINERGIC DRUGS vs PLACEBO | RR 1.11 [0.55, 2.24] | 8 studies · 147 participants | Low Downgraded: risk of bias, imprecision |
Mental state: Deterioration CHOLINERGIC DRUGS vs PLACEBO | RR 0.5 [0.1, 2.61] | 5 studies · 77 participants | Very low Downgraded: risk of bias, imprecision |
Adverse effects: Any adverse events CHOLINERGIC DRUGS vs PLACEBO | RR 0.56 [0.15, 2.14] | 4 studies · 106 participants | Very low Downgraded: risk of bias, imprecision |
Acceptability of treatment: Leaving the study early CHOLINERGIC DRUGS vs PLACEBO | RR 1.09 [0.56, 2.1] | 12 studies · 288 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Social confidence, social inclusion, social networks, or personalised quality of life ‐ not reported CHOLINERGIC DRUGS vs PLACEBO | no estimate extracted | NR | No studies |