Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,584 questions · 3,695 findings · 567 reviews

No studies found 784 · 21.2%GRADE not reported 308 · 8.3%Very low 1,036 · 28%Low 971 · 26.3%Moderate 440 · 11.9%High 156 · 4.2%

Uric acid lowering therapies (UAR) vs Placebo, no intervention or usual care (with or without placebo)

Cardiovascular events · people with CKD

Uric acid lowering therapies (UAR) showed no clear difference in cardiovascular events compared with placebo, no treatment or usual care (low certainty).

1 finding from 1 review

Electrical stimulation plus surgery vs surgery

Cure: number of women with self‐reported continence · women with stress urinary incontinence

It is very uncertain whether electrical stimulation plus surgery changes cure: number of women with self‐reported continence compared with surgery (very low certainty).

1 finding from 1 review

Electrical stimulation plus surgery vs surgery

Improvement: number of women with self‐reported improvement in SUI (cured or improved) · women with stress urinary incontinence

It is very uncertain whether electrical stimulation plus surgery changes improvement: number of women with self‐reported improvement in SUI… compared with surgery (very low certainty).

1 finding from 1 review

NMES vs exercise

Knee pain (short term) VAS scale: 0 to 10; higher score = worse pain. · patients with patellofemoral pain syndrome (symptoms > 4 weeks (1 study); symptoms > 6 weeks (1 study); symptoms > 8 weeks (1 study); not…

The review found no eligible studies for this question.

1 finding from 1 review

NMES vs exercise

Knee function (short term) · patients with patellofemoral pain syndrome (symptoms > 4 weeks (1 study); symptoms > 6 weeks (1 study); symptoms > 8 weeks (1 study); not…

It is very uncertain whether neuromuscular electrical stimulation changes knee function (short term) Arpège function scale (0 to 18; higher… compared with exercise (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Major complications · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes major complications (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Mortality within the longest · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes all‐cause mortality (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Length of hospital stay · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes length of hospital stay (days) compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Surgery‐related complications (during longest · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes surgery‐related complications (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Non‐surgery‐related complications (during longest · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes non‐surgery‐related complications (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Renal failure · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes renal failure (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review