Primary caries prevention · Children and adults (with or without carious lesions)
It is very uncertain whether silver diamine fluoride (SDF) changes primary caries prevention compared with placebo or no treatment (very low certainty).
3 findings from 1 review
MD -1.14 [-1.58, -0.70]
1 study · 373 participants
Very low
MD -0.79 [-1.40, -0.17]
3 studies · 439 participants
Moderate
MD -0.69 [-0.97, -0.41]
1 study · 373 participants
Very low
Secondary prevention of caries · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
3 findings from 1 review
No studies reported data in this dentition type
0 studies
No studies found
MD 0.04 [-0.30, 0.38]
1 study · 309 participants
Very low
No studies reported data in this dentition type
0 studies
No studies found
Primary caries prevention · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Primary caries prevention · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Primary caries prevention · Children and adults (with or without carious lesions)
It is very uncertain whether silver diamine fluoride (SDF) changes primary caries prevention compared with chlorhexidine varnish (very low certainty).
1 finding from 1 review
Secondary prevention of caries · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Secondary prevention of caries · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Dental caries prevalence · Adult residents of slums and non-slum urban settings of LMICs
Dental caries prevalence in LMIC urban/slum populations ranges widely (13%-76%); not GRADE-rated (narrative synthesis).
1 finding from 1 review
Prevalence of dental caries varied across age, gender and socioeconomic class, ranging from 13% (Nigeria) to 76% (Central India); prevalence >50% reported in India, Brazil, Malaysia and Rwanda; generally higher in…
14 studies
GRADE not reported
Oral disease prevalence · Adult residents of slums and non-slum urban settings of LMICs
Oral disease prevalence was generally high and worse in slum settings where compared, but no meta-analysis was conducted.
1 finding from 1 review
no estimate extracted
18 studies
GRADE not reported
Dental caries prevalence · Institutionalized orphan children (roughly 3 to 18 years)
Institutionalized orphan children may be at higher risk of dental caries than parented children (pooled RR 1.19), but the estimate is imprecise and not statistically significant (very low certainty).
1 finding from 1 review
Secondary prevention of caries · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Primary caries prevention · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Secondary prevention of caries · Children and adults (with or without carious lesions)
It is very uncertain whether SDF (given at a particular frequency, concentration, or duration) changes secondary prevention of caries compared with SDF (given at a different frequency, concentration, or duration) (very low certainty).
1 finding from 1 review
Primary caries prevention · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Intervention not reported
Prenatal vitamin D deficiency prevalence
1 finding from 1 review
Primary caries prevention · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Cathepsin K (CT-K) presence/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions
Cathepsin K may be increased in carious dentin (one study), but no certainty rating was assigned (ungraded).
1 finding from 1 review
Higher intensity of immunodetection of CT-K was registered in carious dentin than in sound dentin (Vidal et al., 2014); GRADE was not applied to CT-K.
1 study · 10 participants
GRADE not reported
MMP-13 presence/activity · Human coronal carious dentin and sound dentin
MMP-13 may be increased in carious dentin compared with sound dentin (very low certainty).
1 finding from 1 review
MMP-2 expression/activity · Human ex vivo carious dentin (head/neck radiotherapy)
MMP-2 showed no difference between irradiated and non-irradiated carious dentin (one study; ungraded).
1 finding from 1 review
No significant difference in MMP-2 (gelatinase) expression or activity between irradiated and non-irradiated groups (Gomes-Silva et al., 2017a); GRADE not separately applied to this comparison.
1 study · 36 participants
GRADE not reported
MMP-8 expression/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions
For MMP-8, no clear direction of difference between carious and sound dentin was found; the evidence is very uncertain (very low certainty).
1 finding from 1 review