Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

618 questions · 646 findings · 79 reviews · Neonatal

No studies found 73 · 11.3%GRADE not reported 29 · 4.5%Very low 145 · 22.4%Low 177 · 27.4%Moderate 173 · 26.8%High 49 · 7.6%

Paracetamol vs indomethacin

Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm infants with PDA

Paracetamol showed no clear difference in failure of PDA closure after first course of treatment (assessed by… compared with indomethacin (low certainty).

1 finding from 1 review

Prophylactic administration of paracetamol vs placebo or no intervention

Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm infants with PDA

Prophylactic administration of paracetamol may leads to lower failure of PDA closure after first course (assessed by… compared with placebo or no intervention (low certainty).

1 finding from 1 review

Prophylactic administration of paracetamol vs placebo or no intervention

All‐cause mortality during hospital stay · preterm infants with PDA

Prophylactic administration of paracetamol showed no clear difference in all‐cause mortality during initial hospital stay (by clinical… compared with placebo or no intervention (low certainty).

1 finding from 1 review