Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

662 questions · 720 findings · 164 reviews

No studies found 177 · 24.6%GRADE not reported 126 · 17.5%Very low 144 · 20%Low 139 · 19.3%Moderate 107 · 14.9%High 27 · 3.8%

Autologous platelet concentrates (APC) + open flap debridement (OFD) vs Open flap debridement (access flap surgery)

Pocket closure (complete pocket closure) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
1 finding from 1 review

Rituximab (B cell) + steroid vs steroids

Graft loss or death with a functioning graft · kidney transplant recipients: first rejection episode

Rituximab (B cell) + steroid showed no clear difference in graft loss or death with a functioning graft compared with steroid alone (moderate certainty).

1 finding from 1 review

Rituximab (B cell) + steroid vs steroids

Treatment adverse events: UTI/pyelonephritis · kidney transplant recipients: first rejection episode

Rituximab (B cell) + steroid probably leads to higher treatment adverse events: UTI/pyelonephritis compared with steroid alone (moderate certainty).

1 finding from 1 review

Antibody (T cell) + steroid vs steroids

Graft loss or death with a functioning graft · kidney transplant recipients: first rejection episode

It is very uncertain whether antibody (T cell) + steroid changes graft loss or death with a functioning graft compared with steroid alone (very low certainty).

1 finding from 1 review

External beam radiotherapy (EBRT) plus transarterial chemoembolisation (TACE) vs TACE alone

Mortality Number of deaths at maximum · participants with unresectable hepatocellular carcinoma

External beam radiotherapy (EBRT) plus transarterial… may leads to lower all‐cause mortality (at maximum 1‐year compared with TACE alone (low certainty).

1 finding from 1 review

External beam radiotherapy (EBRT) plus transarterial chemoembolisation (TACE) vs TACE alone

Complete response plus partial response Length of · participants with unresectable hepatocellular carcinoma

External beam radiotherapy (EBRT) plus transarterial… may leads to higher complete response plus partial response Length of compared with TACE alone (low certainty).

1 finding from 1 review

External beam radiotherapy (EBRT) plus transarterial chemoembolisation (TACE) vs TACE alone

Elevated alanine aminotransferase Length of · participants with unresectable hepatocellular carcinoma

It is very uncertain whether external beam radiotherapy (EBRT) plus transarterial… changes elevated alanine aminotransferase Length of compared with TACE alone (very low certainty).

1 finding from 1 review

External beam radiotherapy (EBRT) plus transarterial chemoembolisation (TACE) vs TACE alone

Elevated total bilirubin Length of · participants with unresectable hepatocellular carcinoma

It is very uncertain whether external beam radiotherapy (EBRT) plus transarterial… changes elevated total bilirubin Length of compared with TACE alone (very low certainty).

1 finding from 1 review

Eradication therapy combined with periodontal therapy vs eradication therapy alone

Eradication rate of gastric H. pylori · patients with gastric Helicobacter pylori infection

Eradication therapy combined with periodontal therapy probably leads to higher eradication rate of gastric H. pylori compared with eradication therapy alone (moderate certainty).

1 finding from 1 review

Eradication therapy combined with periodontal therapy vs eradication therapy alone

Non‐recurrence rate of gastric H. pylori · patients with gastric Helicobacter pylori infection

Eradication therapy combined with periodontal therapy may leads to higher non‐recurrence rate of gastric H. pylori compared with eradication therapy alone (low certainty).

1 finding from 1 review

Written information for patients (or parents of child patients) plus prescribing feedback to clinicians vs prescribing feedback alone

Antibiotics prescribed by clinicians · patients (or parents of child patients) with acute upper respiratory tract infections

Written information for patients (or parents of child patients) plus… may leads to higher antibiotics prescribed by clinicians compared with prescribing feedback alone (low certainty).

1 finding from 1 review

Normal saline plus standard treatment vs usual care

Antibiotic usage Patient‐reported usage · patients with acute upper respiratory tract infections

It is very uncertain whether normal saline plus standard treatment changes antibiotic usage Patient‐reported usage compared with standard treatment alone (very low certainty).

1 finding from 1 review