Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

613 questions · 624 findings · 42 reviews · Headline outcomes only

No studies found 85 · 13.6%GRADE not reported 37 · 5.9%Very low 211 · 33.8%Low 181 · 29%Moderate 92 · 14.7%High 18 · 2.9%

Antidepressants vs placebo

Number of responders · patients with depression and dementia

Antidepressant treatment showed no clear difference in number of responders (ITT) at 6 to 12 weeks compared with placebo (low certainty).

1 finding from 1 review