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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Intervention or exposure

Comparison

Outcome

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Review versions

1,645 questions in 107 reviews · Wounds

current versions

No studies 651 · 39.6%Ungraded 84 · 5.1%Very low 554 · 33.7%Low 283 · 17.2%Moderate 64 · 3.9%High 9 · 0.5%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Question	Effect	Evidence	Status / GRADE
Topical phenytoin vs triple antibiotic ointment Time to complete healing · people with a pressure ulcer Topical phenytoin for treating pressure ulcers (2017) · Cochrane	no estimate extracted	NR	No studies
Topical phenytoin vs triple antibiotic ointment Proportion of ulcers healed within trial period (eight weeks) · people with a pressure ulcer Topical phenytoin for treating pressure ulcers (2017) · Cochrane	no estimate extracted	NR	No studies
Topical phenytoin vs triple antibiotic ointment Adverse events · people with a pressure ulcer Topical phenytoin for treating pressure ulcers (2017) · Cochrane	no estimate extracted	1 study · 28 participants	Ungraded
Topical phenytoin vs triple antibiotic ointment Pain · people with a pressure ulcer Topical phenytoin for treating pressure ulcers (2017) · Cochrane	no estimate extracted	1 study · 28 participants	Ungraded
Topical phenytoin group vs a simple dressing Time to complete healing · people with a pressure ulcer Topical phenytoin for treating pressure ulcers (2017) · Cochrane	no estimate extracted	NR	No studies
Antimicrobial dressings vs non‐antimicrobial dressings Proportion of wounds healed Up to 24 weeks' · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	RR 1.28 [1.12, 1.45]	5 studies · 945 participants	Low
One topical antimicrobial agent vs an alternative topical antimicrobial agent Incidence of infection Up to 24 weeks' · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	no estimate extracted	NR	No studies
One topical antimicrobial agent vs an alternative topical antimicrobial agent Resolution of infection Up to 24 weeks' · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	RR 1.45 [0.97, 2.17]	1 study · 37 participants	Very low
One topical antimicrobial agent vs an alternative topical antimicrobial agent Adverse events Up to 24 weeks' · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	no estimate extracted	1 study · 41 participants	Very low
Topical antimicrobial agent vs systemic antimicrobial agent Proportion of wounds healed · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	no estimate extracted	NR	No studies
Topical antimicrobial agent vs systemic antimicrobial agent Incidence of infection · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	no estimate extracted	NR	No studies
Topical antimicrobial agent vs systemic antimicrobial agent Resolution of infection · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	RR 1.51 [0.91, 2.49]	2 studies · 102 participants	Very low
Topical antimicrobial agent vs systemic antimicrobial agent Adverse events · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	RR 0.91 [0.78, 1.06]	4 studies · 937 participants	Moderate
Topical antimicrobial agent vs growth factor Proportion of wounds healed · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	RR 0.5 [0.28, 0.89]	1 study · 40 participants	Very low
Topical antimicrobial agent vs growth factor Incidence of infection · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	no estimate extracted	NR	No studies
Topical antimicrobial agent vs growth factor Resolution of infection · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	no estimate extracted	NR	No studies
Antimicrobial dressings vs non‐antimicrobial dressings Incidence of infection Up to 24 weeks' · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	RR 0.34 [0.04, 3.1]	2 studies · 173 participants	Very low
Topical antimicrobial agent vs growth factor Adverse events · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	no estimate extracted	NR	No studies
Antimicrobial dressings vs non‐antimicrobial dressings Resolution infection · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	no estimate extracted	NR	No studies
Antimicrobial dressings vs non‐antimicrobial dressings Adverse events Up to 24 weeks' · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	RR 0.96 [0.62, 1.48]	1 study · 134 participants	Very low
Topical antimicrobial agents (non‐dressing) vs non‐antimicrobial topical agents (non‐dressing) Proportion of wounds healed Up to 24 weeks' · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	RR 2.82 [0.56, 14.23]	3 studies · 112 participants	Very low
Topical antimicrobial agents (non‐dressing) vs non‐antimicrobial topical agents (non‐dressing) Incidence of infection · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	no estimate extracted	NR	No studies
Topical antimicrobial agents (non‐dressing) vs non‐antimicrobial topical agents (non‐dressing) Resolution of infection Up to 24 weeks' · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	RR 1.16 [0.54, 2.51]	1 study · 40 participants	Low
Topical antimicrobial agents (non‐dressing) vs non‐antimicrobial topical agents (non‐dressing) Adverse events Up to 24 weeks' · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	no estimate extracted	2 studies · 81 participants	Very low
One topical antimicrobial agent vs an alternative topical antimicrobial agent Proportion of wounds healed Up to 24 weeks' · Foot ulcers in people with diabetes Topical antimicrobial agents for treating foot ulcers in people with diabetes (2017) · Cochrane	no estimate extracted	3 studies · 85 participants	Very low
Hydropolymer foam dressing vs silicone foam dressing Incidence of healed pressure ulcers, short‐term · people of any age with an existing pressure ulcer of Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	RR 0.89 [0.45, 1.75]	1 study · 38 participants	Very low
Foam dressing vs hydrogel dressing Time to complete healing · people of any age with an existing pressure ulcer of Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	no estimate extracted	1 study · 34 participants	Very low
Foam dressing vs hydrogel dressing Adverse events, short‐term · people of any age with an existing pressure ulcer of Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	RR 0.33 [0.01, 7.65]	1 study · 34 participants	Very low
Foam dressing vs hydrogel dressing Quality of life · people of any age with an existing pressure ulcer of Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	no estimate extracted	NR	No studies
Foam dressings vs basic contact dressings Incidence of healing, short‐term · people of any age with an existing pressure ulcer Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	RR 1.33 [0.62, 2.88]	1 study · 36 participants	Very low
Foam dressings vs basic contact dressings Incidence of healing, medium‐term · people of any age with an existing pressure ulcer Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	RR 1.17 [0.79, 1.72]	1 study · 50 participants	Very low
Foam dressings vs basic contact dressings Time to complete healing (days) medium‐term · people of any age with an existing pressure ulcer Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	no estimate extracted	1 study · 95 participants	Very low
Foam dressings vs basic contact dressings Adverse events, medium‐term · people of any age with an existing pressure ulcer Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	RR 0.58 [0.33, 1.05]	1 study · 95 participants	Low
Foam dressings vs basic contact dressings Quality of life · people of any age with an existing pressure ulcer Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	no estimate extracted	NR	No studies
Foam dressings vs basic contact dressings Incremental cost per event, short‐term · people of any age with an existing pressure ulcer Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	no estimate extracted	1 study · 36 participants	Very low
Hydropolymer foam dressing vs silicone foam dressing Time to complete healing · people of any age with an existing pressure ulcer of Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	no estimate extracted	NR	No studies
Hydropolymer foam dressing vs silicone foam dressing Adverse events, short‐term · people of any age with an existing pressure ulcer of Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	RR 0.37 [0.04, 3.25]	1 study · 38 participants	Very low
Hydropolymer foam dressing vs silicone foam dressing Quality of life · people of any age with an existing pressure ulcer of Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	no estimate extracted	NR	No studies
Foam dressings vs hydrocolloid dressings Incidence of healing, short‐term · people of any age with an existing pressure ulcer of Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	RR 0.85 [0.54, 1.34]	3 studies · 198 participants	Very low
Foam dressings vs hydrocolloid dressings Time to complete healing · people of any age with an existing pressure ulcer of Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	no estimate extracted	NR	No studies
Foam dressings vs hydrocolloid dressings Adverse events, short‐term · people of any age with an existing pressure ulcer of Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	RR 0.88 [0.37, 2.11]	3 studies · 198 participants	Very low
Foam dressings vs hydrocolloid dressings Quality of life · people of any age with an existing pressure ulcer of Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	no estimate extracted	NR	No studies
Foam dressing vs hydrogel dressing Incidence of healing, short‐term · people of any age with an existing pressure ulcer of Category/Stage II or above Foam dressings for treating pressure ulcers (2017) · Cochrane	RR 1 [0.78, 1.28]	1 study · 34 participants	Very low
Intervention NR Proportion of wounds completely healed at 24 weeks · people with pressure ulcers Anabolic steroids for treating pressure ulcers (2017) · Cochrane	RR 0.81 [0.52, 1.26]	1 study · 212 participants	Very low
Intervention NR Non‐serious adverse events · people with pressure ulcers Anabolic steroids for treating pressure ulcers (2017) · Cochrane	RR 3.85 [1.12, 13.26]	1 study · 212 participants	Low
Intervention NR Serious adverse events · people with pressure ulcers Anabolic steroids for treating pressure ulcers (2017) · Cochrane	RR 0.54 [0.25, 1.17]	1 study · 212 participants	Very low
Metronidazole vs Placebo Malodour (smell score measured on a scale of 0 to 3 with higher scores indicating a more offensive smell) · treating malignant wounds Systemic antibiotics for treating malignant wounds (2017) · Cochrane	no estimate extracted	1 study · 6 participants	Very low
Metronidazole vs Placebo Adverse effects · treating malignant wounds Systemic antibiotics for treating malignant wounds (2017) · Cochrane	no estimate extracted	1 study · 6 participants	Ungraded
Silver‐based antiseptics vs topical antibiotics Wound healing: time to complete healing (time‐to‐event data) · people with burns Antiseptics for burns (2017) · Cochrane	HR 1.25 [0.94, 1.67]	3 studies · 259 participants	Low
Honey vs topical antibiotics Peristent infection: honey versus SSD · people with burns Antiseptics for burns (2017) · Cochrane	RR 0.1 [0.05, 0.19]	2 studies · 170 participants	Very low