Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,345 questions · 4,525 findings · 483 reviews

No studies found 1,024 · 22.6%GRADE not reported 388 · 8.6%Very low 1,172 · 25.9%Low 1,227 · 27.1%Moderate 576 · 12.7%High 138 · 3%

Vaginal surgery with mesh vs non‐mesh repair

Prolapse on examination (Stage 2 or above) ‐ Any recurrent prolapse · women with apical vaginal prolapse

Vaginal surgery with mesh showed no clear difference in prolapse on examination (Stage 2 or above) ‐ Any recurrent prolapse compared with without mesh (low certainty).

1 finding from 1 review

Surgery +/- radiotherapy + (adjuvant) chemotherapy vs Surgery +/- radiotherapy alone (observation or adjuvant radiotherapy only)

Disease-free survival · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Surgery +/- radiotherapy + (adjuvant) chemotherapy led to lower disease-free survival, adjuvant concurrent chemoradiation vs… compared with surgery +/- radiotherapy alone (observation or adjuvant radiotherapy…; GRADE not reported.

1 finding from 1 review

Surgery +/- radiotherapy + (adjuvant) chemotherapy vs Surgery +/- radiotherapy alone (observation or adjuvant radiotherapy only)

Overall survival, adjuvant concomitant chemoradiotherapy vs post-surgery radiotherapy alone · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Surgery +/- radiotherapy + (adjuvant) chemotherapy probably leads to lower overall survival, adjuvant concurrent chemoradiation vs adjuvant… compared with surgery +/- radiotherapy alone (observation or adjuvant radiotherapy… (moderate certainty).

1 finding from 1 review