Femur fracture · European GWAS participants
The SVMR Weighted Median interval included the null.
3 findings from 1 review
OR 1.055 [0.979, 1.136]
489106 participants
GRADE not reported
OR 1.044 [0.983, 1.109]
489106 participants
GRADE not reported
OR 1.063 [0.991, 1.140]
489106 participants
GRADE not reported
Postmenopausal osteoporosis with pathological fracture · European GWAS participants
The SVMR Weighted Median interval included the null.
3 findings from 1 review
OR 0.979 [0.826, 1.159]
281786 participants
GRADE not reported
OR 1.014 [0.872, 1.179]
281786 participants
GRADE not reported
OR 0.934 [0.786, 1.111]
281786 participants
GRADE not reported
Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry)
Genetically predicted periodontitis had no causal effect on postmenopausal osteoporosis with pathological fracture (single-variable MR, OR 1.014).
2 findings from 1 review
Osteoporosis · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 1.005 [0.940, 1.074]
483725 participants
GRADE not reported
Disease control (time when steroid could be discontinued) · bullous pemphigoid
1 finding from 1 review
Mortality at 1 year · bullous pemphigoid
It is very uncertain whether methylprednisolone plus azathioprine changes mortality at 1 year compared with methylprednisolone plus dapsone (very low certainty).
1 finding from 1 review
Quality of life ‐ not measured · bullous pemphigoid
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events at 1 year · bullous pemphigoid
1 finding from 1 review
Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years)
Mean dmft was lowest (1.62 teeth) in low-inequality countries by Gini index.
16 findings from 1 review
Show 13 more findings
MEAN 3.34 [1.79, 4.88]
13 studies
GRADE not reported
MEAN 4.64 [3.38, 5.91]
19 studies
GRADE not reported
MEAN 3.87 [2.84, 4.91]
30 studies
GRADE not reported
MEAN 3.89 [1.62, 6.16]
7 studies
GRADE not reported
MEAN 4.04 [2.39, 5.68]
9 studies
GRADE not reported
A systematic review and meta-analysis on early-childhood-caries global data. 2024 All outcomesCountries with 71-75 years life expectancy · Life expectancy: 71-75 years
MEAN 5.18
Studies not reported
GRADE not reported
MEAN 4.28 [2.58, 5.97]
10 studies
GRADE not reported
A systematic review and meta-analysis on early-childhood-caries global data. 2024 All outcomesCountries with no income inequality (Gini) · Gini index: no inequalities
MEAN 3.95
Studies not reported
GRADE not reported
MEAN 3.08 [2.42, 3.74]
3 studies
GRADE not reported
A systematic review and meta-analysis on early-childhood-caries global data. 2024 All outcomes49 countries worldwide; urban and rural communities · Overall (all regions)
MEAN 3.68 [2.99, 4.37]
60 studies
GRADE not reported
MEAN 1.13 [0.72, 1.55]
9 studies
GRADE not reported
MEAN 2.26 [0.69, 3.82]
11 studies
GRADE not reported
A systematic review and meta-analysis on early-childhood-caries global data. 2024 All outcomesCountries with highest life expectancy (>80 years) · Life expectancy: >80 years
MEAN 1.34
Studies not reported
GRADE not reported
Femur fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 0.820 [0.618, 1.087]
489106 participants
GRADE not reported
Forearm fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 0.901 [0.751, 1.081]
490889 participants
GRADE not reported
Postmenopausal osteoporosis with pathological fracture · European GWAS participants
The SVMR Maximum Likelihood interval included the null.
3 findings from 1 review
OR 1.363 [0.955, 1.947]
281786 participants
GRADE not reported
OR 1.355 [0.696, 2.635]
281786 participants
GRADE not reported
OR 1.214 [0.746, 1.977]
281786 participants
GRADE not reported
Osteoporosis with pathological fracture · European GWAS participants
The SVMR MR-Egger interval included the null.
3 findings from 1 review
OR 1.097 [0.598, 2.011]
376746 participants
GRADE not reported
OR 1.181 [0.748, 1.866]
376746 participants
GRADE not reported
OR 1.278 [0.921, 1.773]
376746 participants
GRADE not reported
Femur fracture · European GWAS participants
The SVMR MR-Egger interval included the null.
3 findings from 1 review
OR 0.893 [0.678, 1.175]
489106 participants
GRADE not reported
OR 1.137 [0.976, 1.325]
489106 participants
GRADE not reported
OR 1.094 [0.884, 1.354]
489106 participants
GRADE not reported
Lumbar spine and pelvis fracture · European GWAS participants
The SVMR Weighted Median interval included the null.
3 findings from 1 review
OR 0.867 [0.691, 1.087]
490700 participants
GRADE not reported
OR 0.950 [0.808, 1.117]
490700 participants
GRADE not reported
OR 0.994 [0.729, 1.355]
490700 participants
GRADE not reported
Osteoporosis · European GWAS participants
The MVMR MR-Egger interval excluded the null.
1 finding from 1 review
OR 1.343 [1.015, 1.778]
483725 participants
GRADE not reported
Lumbar spine bone mineral density (BMD) · European GWAS participants
The SVMR IVW interval excluded zero.
1 finding from 1 review
Osteoporosis · European GWAS participants
The SVMR Weighted Median interval excluded the null.
3 findings from 1 review
OR 1.260 [1.017, 1.560]
483725 participants
GRADE not reported
OR 1.162 [0.998, 1.353]
483725 participants
GRADE not reported
OR 1.329 [0.991, 1.782]
483725 participants
GRADE not reported
Lumbar spine and pelvis fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 1.034 [0.769, 1.390]
490700 participants
GRADE not reported
Postmenopausal osteoporosis with pathological fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 1.281 [0.640, 2.565]
281786 participants
GRADE not reported