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Evidence found and GRADE certainty

3,092 questions · 3,199 findings · 339 reviews · Headline outcomes only

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No studies found 714 · 22.3%GRADE not reported 181 · 5.7%Very low 695 · 21.7%Low 908 · 28.4%Moderate 568 · 17.8%High 133 · 4.2%

Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID

Global assessment of treatment success · patients with adhesive capsulitis (frozen shoulder)

Combination of manual therapy, exercise, electrotherapy and oral NSAID may leads to higher global assessment of treatment success "Disappearance of shoulder… compared with oral NSAID (low certainty).

1 finding from 1 review

Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID

Adverse events Pain persisting longer than 2 hours after treatment (during the 3‐week treatment period) · patients with adhesive capsulitis (frozen shoulder)

Combination of manual therapy, exercise, electrotherapy and oral NSAID may leads to higher adverse events Pain persisting longer than 2 hours after treatment… compared with oral NSAID (low certainty).

1 finding from 1 review

Summary of findings table ‐ Oral small molecule inhibitors (ruxolitinib) vs oral small molecule inhibitors (tofacitinib)

Short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of · adults with alopecia areata

It is very uncertain whether summary of findings table ‐ Oral small molecule inhibitors… changes short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of compared with oral small molecule inhibitors (tofacitinib) (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Oral classical immunosuppressants (betamethasone) vs oral classical immunosuppressants (azathioprine, methotrexate, prednisolone)

Short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of · adults with alopecia areata

Summary of findings table ‐ Oral classical immunosuppressants… showed no clear difference in short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of compared with oral classical immunosuppressants (azathioprine, methotrexate,… (low certainty).

1 finding from 1 review

Oral factor Xa inhibitors vs conventional anticoagulation

Non‐fatal PE (3 to 12 months) · participants with diagnosed DVT

Oral factor Xa inhibitors showed no clear difference in non‐fatal PE (3 to 12 months) compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral factor Xa inhibitors vs conventional anticoagulation

All‐cause mortality (3 to 6 months) · participants with diagnosed DVT

Oral factor Xa inhibitors showed no clear difference in all‐cause mortality (3 to 6 months) compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral factor Xa inhibitors vs conventional anticoagulation

Recurrent DVT (3 to 12 months) · participants with diagnosed DVT

Oral factor Xa inhibitors showed no clear difference in recurrent DVT (3 to 12 months) compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral factor Xa inhibitors vs conventional anticoagulation

Fatal PE (3 to 12 months) · participants with diagnosed DVT

Oral factor Xa inhibitors showed no clear difference in fatal PE (3 to 12 months) compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review