Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

521 questions · 544 findings · 62 reviews

No studies found 153 · 28.1%GRADE not reported 29 · 5.3%Very low 134 · 24.6%Low 123 · 22.6%Moderate 80 · 14.7%High 25 · 4.6%

Vaginal misoprostol vs placebo

Opiate use (as a proxy measure for pain) for all participants on ITT (including those without confirmed AMI) · early fetal death (less than 24 weeks)

It is very uncertain whether vaginal misoprostol changes pain (opiate use) compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Duration of hospitalization (in weeks) · individuals with infant botulism
1 finding from 1 review

Intervention not reported

Duration of mechanical ventilation (in weeks) · individuals with infant botulism
1 finding from 1 review

Intervention not reported

Duration of tube or parenteral feeding (in weeks) · individuals with infant botulism
1 finding from 1 review

Intervention not reported

Risk of adverse events (until time of hospital discharge) · individuals with infant botulism

The intervention showed no clear difference in risk of adverse events (until time of hospital discharge) (moderate certainty).

1 finding from 1 review