Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,970 questions · 2,433 findings · 231 reviews

No studies found 303 · 12.5%GRADE not reported 759 · 31.2%Very low 357 · 14.7%Low 476 · 19.6%Moderate 418 · 17.2%High 120 · 4.9%

Down syndrome vs Individuals without Down syndrome (healthy controls: siblings, schoolchildren or others)

Mean DMFT (decayed, missing, filled permanent teeth) · Individuals of all ages

Individuals with Down syndrome had a lower mean DMFT in permanent teeth than controls (pooled SMD -0.18, 95% CI -0.35 to -0.02; 6 studies; I2=20%); certainty of evidence not graded.

1 finding from 1 review

Down syndrome vs Individuals without Down syndrome (healthy controls: siblings, schoolchildren or others)

Dental caries · Individuals of all ages

Individuals with Down syndrome had a lower prevalence of dental caries than those without (pooled OR 0.36, 95% CI 0.22 to 0.57; 2 studies; I2=0%); certainty of evidence not graded.

1 finding from 1 review

Summary of findings table ‐ routine monitoring vs no routine monitoring of gastric residual

Risk of necrotising enterocolitis stage ≥ 2 · preterm infants

Summary of findings table ‐ routine monitoring showed no clear difference in risk of necrotising enterocolitis stage ≥ 2 compared with no routine monitoring of gastric residual (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ routine monitoring vs no routine monitoring of gastric residual

Number of infants with feed interruption episodes (lasting ≥ 12 hours) · preterm infants

Summary of findings table ‐ routine monitoring may leads to higher number of infants with feed interruption episodes (lasting ≥ 12 hours) compared with no routine monitoring of gastric residual (low certainty).

1 finding from 1 review

Summary of findings table ‐ routine monitoring vs no routine monitoring of gastric residual

Risk of invasive Infection · preterm infants

Summary of findings table ‐ routine monitoring probably leads to higher risk of invasive infection compared with no routine monitoring of gastric residual (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ routine monitoring vs no routine monitoring of gastric residual

Mortality before hospital discharge · preterm infants

Summary of findings table ‐ routine monitoring showed no clear difference in all‐cause mortality before hospital discharge compared with no routine monitoring of gastric residual (low certainty).

1 finding from 1 review

Summary of findings table ‐ Re‐feeding vs discarding gastric residuals

Mortality before hospital discharge · preterm infants

Summary of findings table ‐ Re‐feeding showed no clear difference in all‐cause mortality before hospital discharge compared with discarding gastric residuals (low certainty).

1 finding from 1 review

Summary of findings table ‐ Re‐feeding vs discarding gastric residuals

Number of infants with feed interruption episodes (lasting ≥ 12 hours) · preterm infants

It is very uncertain whether summary of findings table ‐ Re‐feeding changes number of infants with feed interruption episodes lasting ≥ 12 hours compared with discarding gastric residuals (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Re‐feeding vs discarding gastric residuals

Extrauterine growth restriction at discharge · preterm infants

Summary of findings table ‐ Re‐feeding showed no clear difference in risk of extrauterine growth restriction at discharge compared with discarding gastric residuals (low certainty).

1 finding from 1 review