Findings

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Evidence found and GRADE certainty

2,447 questions · 2,590 findings · 266 reviews

No studies found 699 · 27%GRADE not reported 289 · 11.2%Very low 614 · 23.7%Low 605 · 23.4%Moderate 322 · 12.4%High 61 · 2.4%

38% SDF (every 6 months) vs no treatment

Inactive (arrested) carious lesions on permanent first molars · Children with dental caries in permanent (first) molars

Six-monthly SDF produced significantly more inactive (arrested) lesions than no treatment in children's permanent molars (0.3 vs 0.1; p<0.05; ungraded).

1 finding from 1 review

Dexrazoxane vs no cardioprotective intervention

Tumour response rate Defined as number of complete responses (i.e. disappearance of active Hodgkin lymphoma (gallium negative, ≥ 70% decrease in the sum of the products of the perpendicular diameters of measurable lesions, and negative bone marrow... · children with cancer receiving anthracyclines

Dexrazoxane showed no clear difference in tumour response rate Defined as number of complete responses (i.e.… compared with no cardioprotective intervention (low certainty).

1 finding from 1 review

Periodontal treatment: scaling and root planing (SRP) plus advice vs Community care: advice only

Serum high-sensitivity C-reactive protein (hs-CRP) · Patients with cardiovascular disease and chronic periodontitis
1 finding from 1 review

Transurethral microwave thermotherapy vs transurethral resection of the prostate

Erectile function · men with lower urinary tract symptoms secondary to benign prostatic obstruction

Transurethral microwave thermotherapy showed no clear difference in erectile function (sexually‐active men only) compared with transurethral resection of the prostate (low certainty).

1 finding from 1 review

Transurethral microwave thermotherapy vs transurethral resection of the prostate

Ejaculatory function · men with lower urinary tract symptoms secondary to benign prostatic obstruction

Transurethral microwave thermotherapy may leads to lower ejaculatory function (sexually‐active men only) compared with transurethral resection of the prostate (low certainty).

1 finding from 1 review

Interventions delivered by dental professionals vs control

Smoking cessation · participants who used tobacco products

It is very uncertain whether interventions delivered by dental professionals changes multi‐session behavioural support versus usual care, brief advice,… compared with control (very low certainty).

1 finding from 1 review

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

Infection or inflammation at individual level (as measured by urinary neopterin, C‐reactive protein or alpha‐1‐acid glycoprotein variant A) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review