Time to 12‐month remission ‐ all participants Range of · adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure…
Summary of findings: lamotrigine showed no clear difference in time to 12‐month remission All participants Range of compared with carbamazepine (high certainty).
1 finding from 1 review
Time to treatment failure (any reason related to treatment) All participants Range of · adults and children with newly onset partial or generalised epilepsy
Carbamazepine probably leads to lower time to treatment failure (any reason related to treatment) All… compared with phenobarbitone (moderate certainty).
1 finding from 1 review
Time to treatment failure (any reason related to treatment) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy
Carbamazepine may leads to lower time to treatment failure (any reason related to treatment)… compared with phenobarbitone (low certainty).
1 finding from 1 review
Time to treatment failure (any reason related to treatment) Subgroup: generalised onset seizures (tonic‐clonic only) Range of · adults and children with newly onset partial or generalised epilepsy
Carbamazepine showed no clear difference in time to treatment failure (any reason related to treatment)… compared with phenobarbitone (low certainty).
1 finding from 1 review
Time to first seizure (post‐randomisation) All participants Range of · adults and children with newly onset partial or generalised epilepsy
Carbamazepine showed no clear difference in time to first seizure (post‐randomisation) All participants Range of compared with phenobarbitone (moderate certainty).
1 finding from 1 review
Time to first seizure (post‐randomisation) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy
Carbamazepine probably leads to higher time to first seizure (post‐randomisation) Subgroup: focal onset… compared with phenobarbitone (moderate certainty).
1 finding from 1 review
Time to first seizure (post‐randomisation) ‐ stratified by epilepsy type: generalised onset seizures (tonic‐clonic only) Range of · adults and children with newly onset partial or generalised epilepsy
Carbamazepine showed no clear difference in time to first seizure (post‐randomisation) Subgroup: generalised… compared with phenobarbitone (low certainty).
1 finding from 1 review
Remission · adults and children with newly onset partial or generalised epilepsy
Carbamazepine showed no clear difference in time to achieve 12‐month remission (seizure‐free period) All… compared with phenobarbitone (low certainty).
1 finding from 1 review
Time to achieve 12‐month remission (seizure‐free period) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy
Carbamazepine showed no clear difference in time to achieve 12‐month remission (seizure‐free period) Subgroup:… compared with phenobarbitone (low certainty).
1 finding from 1 review
Time to 12‐month remission ‐ stratified by epilepsy type ‐ Generalized onset seizures (tonic‐clonic only) Range of · adults and children with newly onset partial or generalised epilepsy
Carbamazepine showed no clear difference in time to achieve 12‐month remission (seizure‐free period) Subgroup:… compared with phenobarbitone (low certainty).
1 finding from 1 review
Maternal · women with mild to moderate hypertension during pregnancy
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Severe pre‐eclampsia · women with mild to moderate hypertension during pregnancy
It is very uncertain whether any antihypertensive drug changes severe pre‐eclampsia compared with no antihypertensive drugs/placebo (very low certainty).
1 finding from 1 review
Eclampsia · women with mild to moderate hypertension during pregnancy
It is very uncertain whether any antihypertensive drug changes eclampsia compared with no antihypertensive drugs/placebo (very low certainty).
1 finding from 1 review
Changed/stopped drugs due to maternal side‐effects · women with mild to moderate hypertension during pregnancy
Any antihypertensive drug showed no clear difference in changed/stopped drugs due to maternal side‐effects compared with no antihypertensive drugs/placebo (low certainty).
1 finding from 1 review
Elective delivery (induction of labour + elective caesarean section) · women with mild to moderate hypertension during pregnancy
Any antihypertensive drug showed no clear difference in elective delivery (induction of labour + elective caesarean section) compared with no antihypertensive drugs/placebo (moderate certainty).
1 finding from 1 review
Fetal/neonatal/infant · women with mild to moderate hypertension during pregnancy
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Admission to neonatal or intensive care nursery · women with mild to moderate hypertension during pregnancy
Any antihypertensive drug showed no clear difference in admission to neonatal or intensive care nursery compared with no antihypertensive drugs/placebo (low certainty).
1 finding from 1 review
Severe hypertension · women with mild to moderate hypertension during pregnancy
Any antihypertensive drug probably leads to lower severe hypertension compared with no antihypertensive drugs/placebo (moderate certainty).
1 finding from 1 review
Proteinuria/pre‐eclampsia · women with mild to moderate hypertension during pregnancy
Any antihypertensive drug showed no clear difference in proteinuria/pre‐eclampsia compared with no antihypertensive drugs/placebo (low certainty).
1 finding from 1 review
Total reported fetal or neonatal deaths (including miscarriage) · women with mild to moderate hypertension during pregnancy
Any antihypertensive drug showed no clear difference in total reported fetal or neonatal deaths (including miscarriage) compared with no antihypertensive drugs/placebo (moderate certainty).
1 finding from 1 review