Findings

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Evidence found and GRADE certainty

4,771 questions · 10,185 findings · 893 reviews

No studies found 2,109 · 20.7%GRADE not reported 1,125 · 11%Very low 2,279 · 22.4%Low 2,514 · 24.7%Moderate 1,709 · 16.8%High 449 · 4.4%

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ECT plus standard care vs sham‐ECT plus standard care

Service use (short term) ‐ hospitalisation (number readmitted) · people with treatment‐resistant schizophrenia

ECT plus standard care may leads to lower service use (short term) ‐ hospitalisation (number readmitted) compared with sham‐ECT plus standard care (low certainty).

1 finding from 1 review

ECT plus standard care vs antipsychotics plus standard care

Response to treatment (medium term) Clinically important response to treatment as defined by each study · people with treatment‐resistant schizophrenia

ECT plus standard care showed no clear difference in response to treatment (medium term) Clinically important response to… compared with antipsychotics plus standard care (low certainty).

1 finding from 1 review

Topiramate vs carbamazepine

Time to treatment failure (any reason related to treatment) All participants ‐ adjusted by seizure type Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate showed no clear difference in time to treatment failure (any reason related to treatment) All… compared with carbamazepine (moderate certainty).

1 finding from 1 review

Topiramate vs carbamazepine

Time to treatment failure (any reason related to treatment) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate probably leads to higher time to treatment failure (any reason related to treatment)Subgroup:… compared with carbamazepine (moderate certainty).

1 finding from 1 review

Topiramate vs carbamazepine

Time to treatment failure (any reason related to treatment) Subgroup: generalised onset tonic‐clonic seizures or unclassified epilepsy Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate showed no clear difference in time to treatment failure (any reason related to treatment)… compared with carbamazepine (low certainty).

1 finding from 1 review

Topiramate vs carbamazepine

Time to first seizure (post‐randomisation) All participants Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate showed no clear difference in time to first seizure after randomisation All participants Range of compared with carbamazepine (high certainty).

1 finding from 1 review