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What do systematic reviews say?

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Evidence found and GRADE certainty

4,736 questions · 15,265 findings · 1,163 reviews · Headline outcomes only

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No studies found 3,871 · 25.4%GRADE not reported 810 · 5.3%Very low 4,242 · 27.8%Low 3,879 · 25.4%Moderate 1,999 · 13.1%High 464 · 3%

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Central monitoring with triggered vs untriggered on‐site visits

Sites ≥ 1 major monitoring finding combined outcome · clinical trials in all fields of health care

Central monitoring with triggered showed no clear difference in sites ≥ 1 major monitoring finding combined outcome compared with untriggered on‐site visits (low certainty).

1 finding from 1 review

Central and local monitoring only vs central and local monitoring with on‐site visits

Combined outcome of proportion of participants with major or critical monitoring findings · clinical trials in all fields of health care

Central and local monitoring only probably leads to higher combined outcome of proportion of participants with major or… compared with central and local monitoring with on‐site visits (moderate certainty).

1 finding from 1 review