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Early taxane‐based chemotherapy and androgen deprivation therapy (ADT) may leads to higher grade III to V adverse events compared with ADT only (low certainty).
Early taxane‐based chemotherapy and androgen deprivation therapy (ADT) probably leads to lower prostate cancer‐specific death5 compared with ADT only (moderate certainty).
Early taxane‐based chemotherapy and androgen deprivation therapy (ADT) probably leads to lower time to progression (absolute effect size estimates based on… compared with ADT only (moderate certainty).
Early taxane‐based chemotherapy and androgen deprivation therapy (ADT) may leads to higher discontinuation due to adverse events compared with ADT only (low certainty).
Early taxane‐based chemotherapy and androgen deprivation therapy (ADT) may leads to higher all adverse events compared with ADT only (low certainty).
Oral ivermectin 200 μg/kg (1 to 3 doses) showed no clear difference in complete clearance ‐ week 1 compared with topical ivermectin 1% lotion/solution (1 to 3 applications) (low certainty).
It is very uncertain whether oral ivermectin 200 μg/kg (1 to 3 doses) changes number of participants with ≥ 1 AE ‐ week 4 compared with topical ivermectin 1% lotion/solution (1 to 3 applications) (very low certainty).
Oral ivermectin 200 μg/kg (1 dose) showed no clear difference in complete clearance ‐ week 4 compared with oral ivermectin 200 μg/kg (2 doses) (high certainty).
The intervention showed no clear difference in overall survival## (moderate certainty).
The intervention showed no clear difference in progression‐free survival### (low certainty).
The intervention probably leads to lower vertebral fractures (moderate certainty).
The intervention showed no clear difference in non‐vertebral fractures (moderate certainty).
The intervention probably leads to lower skeletal‐related events (moderate certainty).
It is very uncertain whether the intervention changes pain (very low certainty).
The intervention showed no clear difference in osteonecrosis of jaw (low certainty).
Absorbable showed no clear difference in incisional hernia compared with non‐absorbable sutures (moderate certainty).
Continuous showed no clear difference in wound infection at last compared with interrupted closure (moderate certainty).