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What do systematic reviews say?

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Evidence found and GRADE certainty

492 questions · 535 findings · 56 reviews · Hypertension

No studies found 37 · 6.9%GRADE not reported 34 · 6.4%Very low 91 · 17%Low 161 · 30.1%Moderate 136 · 25.4%High 76 · 14.2%

Intervention not reported

Angiotensin receptor blocker (high‐ versus medium‐dose) · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
1 finding from 1 review

Intervention not reported

Angiotensin receptor blocker (medium‐ versus low‐dose) · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
1 finding from 1 review

Intervention not reported

High‐ versus low‐dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
1 finding from 1 review

Intervention not reported

High‐ versus medium‐dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
1 finding from 1 review

Intervention not reported

Medium‐ versus low‐dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
1 finding from 1 review

Intervention not reported

Angiotensin‐converting enzyme inhibitor · children (from 1 to 18 years of age) with hypertension from primary or secondary causes

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

High‐ versus low‐dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
1 finding from 1 review

Intervention not reported

High‐ versus medium‐ dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
1 finding from 1 review

Intervention not reported

Medium‐ versus low‐dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
1 finding from 1 review

Intervention not reported

High‐ versus low‐dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
1 finding from 1 review

Antihypertensive drug class vs placebo

Beta‐blocker (any dose) Mean duration of 4 weeks · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
2 findings from 1 review

Intervention not reported

High‐ versus medium‐dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
1 finding from 1 review

Intervention not reported

Medium‐ versus low‐dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
1 finding from 1 review

Intervention not reported

High vs low dose Systolic blood pressure · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
1 finding from 1 review

Intervention not reported

High vs low dose Diastolic blood pressure · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
1 finding from 1 review

Antihypertensive drug class vs placebo

Calcium channel blocker (any dose) Mean duration of 3 weeks · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
2 findings from 1 review

Antihypertensive drug class vs placebo

Beta‐blocker/thiazide combination (any dose) Mean duration of 10 weeks · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
2 findings from 1 review

Intervention not reported

Angiotensin receptor blocker (high‐ versus low‐dose) · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs ARB

Total mortality · people with primary hypertension

All angiotensin converting enzyme (ACE) inhibitors showed no clear difference in total mortality compared with all angiotensin receptor blockers (ARBs) (moderate certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs ARB

Cardiovascular events · people with primary hypertension

All angiotensin converting enzyme (ACE) inhibitors showed no clear difference in total cardiovascular events compared with all angiotensin receptor blockers (ARBs) (low certainty).

1 finding from 1 review