Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

568 questions · 575 findings · 105 reviews

No studies found 53 · 9.2%GRADE not reported 26 · 4.5%Very low 91 · 15.8%Low 215 · 37.4%Moderate 151 · 26.3%High 39 · 6.8%

DCC with immediate neonatal care after cord clamping vs ECC (subgroup analysis by gestation)

Severe intraventricular haemorrhage · babies born preterm, and their mothers

DCC with immediate neonatal care after cord clamping showed no clear difference in severe intraventricular haemorrhage (IVH grades 3, 4) compared with ECC (subgroup analysis by gestation) (low certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs ECC (subgroup analysis by gestation)

Intraventricular haemorrhage · babies born preterm, and their mothers

DCC with immediate neonatal care after cord clamping leads to lower intraventricular haemorrhage (IVH, all grades) compared with ECC (subgroup analysis by gestation) (high certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs ECC (subgroup analysis by gestation)

Periventricular leukomalacia · babies born preterm, and their mothers

DCC with immediate neonatal care after cord clamping showed no clear difference in periventricular leukomalacia (PVL) compared with ECC (subgroup analysis by gestation) (low certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs ECC (subgroup analysis by gestation)

Chronic lung disease · babies born preterm, and their mothers

DCC with immediate neonatal care after cord clamping showed no clear difference in chronic lung disease (CLD) ‐ oxygen supplement at 36 weeks… compared with ECC (subgroup analysis by gestation) (high certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs ECC (subgroup analysis by gestation)

Maternal blood loss of 500 mL or greater · babies born preterm, and their mothers

It is very uncertain whether DCC with immediate neonatal care after cord clamping changes maternal blood loss of 500 mL or greater compared with ECC (subgroup analysis by gestation) (very low certainty).

1 finding from 1 review

DCC with immediate neonatal care with cord intact vs ECC

Death of baby (up to discharge) · babies born preterm, and their mothers

DCC with immediate neonatal care with cord intact showed no clear difference in death of baby (up to discharge) compared with ECC (low certainty).

1 finding from 1 review

DCC with immediate neonatal care with cord intact vs ECC

Death or neurodevelopmental impairment at age 2 to 3 years · babies born preterm, and their mothers

DCC with immediate neonatal care with cord intact may leads to lower death or neurodevelopmental impairment at age 2 to 3 years compared with ECC (low certainty).

1 finding from 1 review

Inhaled steroids vs systemic corticosteroids

BPD or death at 36 weeks' postmenstrual age№ of participants: 0 (0 RCTs) · preterm infants with respiratory distress for initial respiratory support

Inhaled steroids showed no clear difference in death or BPD at 36 weeks' postmenstrual age among all randomised compared with systemic corticosteroids (moderate certainty).

1 finding from 1 review

Inhaled steroids vs systemic corticosteroids

Death or BPD (28 days) · preterm infants with respiratory distress for initial respiratory support

Inhaled steroids showed no clear difference in death or BPD at 28 days compared with systemic corticosteroids (low certainty).

1 finding from 1 review

Inhaled steroids vs systemic corticosteroids

Bronchopulmonary dysplasia/chronic lung disease · preterm infants with respiratory distress for initial respiratory support

Inhaled steroids showed no clear difference in BPD at 36 weeks' postmenstrual age compared with systemic corticosteroids (moderate certainty).

1 finding from 1 review