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Evidence found and GRADE certainty

628 questions · 651 findings · 39 reviews · Skin

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No studies found 167 · 25.7%GRADE not reported 47 · 7.2%Very low 80 · 12.3%Low 139 · 21.4%Moderate 174 · 26.7%High 44 · 6.8%

Doxycycline 40 mg vs placebo

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Doxycycline 40 mg vs placebo

Participant‐assessed improvement in rosacea severity ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Metronidazole vs placebo

Duration of remission · Participants with rosacea

Metronidazole probably leads to lower duration of remission compared with placebo (moderate certainty).

1 finding from 1 review

Doxycycline 40 mg vs placebo

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Azelaic acid vs placebo

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Ketoconazole vs placebo

Failure to achieve complete resolution Clinical assessment · patients with seborrhoeic dermatitis

Ketoconazole may leads to lower failure to achieve complete resolution Clinical assessment compared with placebo (low certainty).

1 finding from 1 review

Ciclopirox vs placebo

Side effects (combined for face and scalp) Self report · patients with seborrhoeic dermatitis

Ciclopirox showed no clear difference in side effects (combined for face and scalp) Self reported compared with placebo (moderate certainty).

1 finding from 1 review

Ketoconazole vs placebo

Side effects Self report · patients with seborrhoeic dermatitis

It is very uncertain whether ketoconazole changes side effects Self report compared with placebo (very low certainty).

1 finding from 1 review

Ciclopirox vs placebo

Failure to achieve complete resolution (combined for face and scalp) Clinical assessment · patients with seborrhoeic dermatitis

Ciclopirox probably leads to lower failure to achieve complete resolution (combined for face and scalp)… compared with placebo (moderate certainty).

1 finding from 1 review

Etanercept vs placebo

Percentage of participants reaching PASI 75 · people with paediatric psoriasis

Etanercept leads to higher PASI 75 Participants achieving a 75% improvement in the Psoriasis… compared with placebo (high certainty).

1 finding from 1 review

Etanercept vs placebo

PASI 50 · people with paediatric psoriasis

Etanercept leads to higher PASI 50 Participants achieving a 50% improvement in the Psoriasis… compared with placebo (high certainty).

1 finding from 1 review

Etanercept vs placebo

PASI 90 · people with paediatric psoriasis

Etanercept leads to higher PASI 90 Participants achieving a 90% improvement in the Psoriasis… compared with placebo (high certainty).

1 finding from 1 review

Etanercept vs placebo

PGA Participants achieving a PGA of 'clear' or 'almost clear' · people with paediatric psoriasis

Etanercept leads to higher PGA Participants achieving a PGA of 'clear' or 'almost clear' compared with placebo (high certainty).

1 finding from 1 review

Etanercept vs placebo

CDLQI Scores range from 0 to 30. Lower scores indicate better health‐related quality of life. Calculations are based on the change from baseline to week 12 in both groups · people with paediatric psoriasis
1 finding from 1 review