Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,340 questions · 1,512 findings · 205 reviews

No studies found 317 · 21%GRADE not reported 358 · 23.7%Very low 356 · 23.5%Low 271 · 17.9%Moderate 173 · 11.4%High 37 · 2.4%

Intervention not reported

Peritoneal lavage vs. open necrosectomy · people with necrotising pancreatitis

It is very uncertain whether the intervention changes peritoneal lavage vs. open necrosectomy (very low certainty).

1 finding from 1 review

Intervention not reported

Minimally invasive step‐up approach vs. open necrosectomy · people with necrotising pancreatitis

It is very uncertain whether the intervention changes minimally invasive step‐up approach vs. open necrosectomy (very low certainty).

1 finding from 1 review

Intervention not reported

Delayed open necrosectomy vs. early open necrosectomy · people with necrotising pancreatitis

It is very uncertain whether the intervention changes delayed open necrosectomy vs. early open necrosectomy (very low certainty).

1 finding from 1 review

Intervention not reported

Minimally invasive step‐up approach vs. open necrosectomy · people with necrotising pancreatitis

It is very uncertain whether the intervention changes minimally invasive step‐up approach vs. open necrosectomy (very low certainty).

1 finding from 1 review

Intervention not reported

Peritoneal lavage vs. open necrosectomy · people with necrotising pancreatitis

It is very uncertain whether the intervention changes peritoneal lavage vs. open necrosectomy (very low certainty).

1 finding from 1 review

Intervention not reported

Open surgical drainage versus EUS‐guided drainage · patients with pancreatic pseudocysts

It is very uncertain whether the intervention changes open surgical drainage versus EUS‐guided drainage (very low certainty).

1 finding from 1 review

Intervention not reported

Open surgical drainage versus EUS‐guided drainage · patients with pancreatic pseudocysts
1 finding from 1 review

Intervention not reported

Open surgical drainage versus EUS‐guided drainage Scale from: 0 to 100. Higher indicates better · patients with pancreatic pseudocysts
1 finding from 1 review

Ruxolitinib vs best available therapy

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · Patients with treating MF

Ruxolitinib showed no clear difference in safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4… compared with best available therapy (low certainty).

1 finding from 1 review

Ruxolitinib vs placebo

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · Patients with treating MF

Ruxolitinib may leads to higher safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4… compared with placebo (low certainty).

1 finding from 1 review

Non‐platinum therapies vs platinum combination

Grade 3 or higher hematological toxicity for platinum therapies ‐ thrombocytopenia · non‐small cell lung cancer in the elderly population

Non‐platinum therapies may leads to higher grade 3 or higher hematological toxicity for platinum therapies ‐… compared with platinum combination (low certainty).

1 finding from 1 review

Non‐platinum single‐agent vs non‐platinum combination treatment

Grade 3 to 4 neutropenia · non‐small cell lung cancer in the elderly population

Non‐platinum single‐agent may leads to higher grade 3 and 4 hematological adverse events (AE) ‐ neutropenia compared with non‐platinum combination treatment (low certainty).

1 finding from 1 review

Non‐platinum single‐agent vs non‐platinum combination treatment

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · non‐small cell lung cancer in the elderly population

It is very uncertain whether non‐platinum single‐agent changes grade 3 and 4 hematological adverse events (AE) ‐ thrombocytopenia compared with non‐platinum combination treatment (very low certainty).

1 finding from 1 review

Rapid COJEC vs standard induction therapies

Early toxicities (during preoperative chemotherapy): febrile neutropenia (2 or more episodes), proven fungal infections, septicemia (1 or more episodes), gastrointestinal toxicity (grade 3 or 4), renal toxicity (glomerular filtration rate < 80 ml/... · patients with high‐risk neuroblastoma
1 finding from 1 review

Intervention not reported

The proportion of patients with lymphopenia at two years · Patients with relapsing‐remitting multiple sclerosis

The intervention probably leads to higher the proportion of patients with lymphopenia at two years (moderate certainty).

1 finding from 1 review