Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,760 questions · 8,065 findings · 1,036 reviews

No studies found 1,686 · 20.9%GRADE not reported 675 · 8.4%Very low 1,953 · 24.2%Low 2,048 · 25.4%Moderate 1,296 · 16.1%High 407 · 5%

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HFNC vs continuous positive airway pressure (CPAP)

BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in BPD (supplemental oxygen/respiratory support at 36 weeks'… compared with continuous positive airway pressure (low certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Treatment failure within 72 hours of trial entry · preterm infants requiring primary respiratory support

Nasal high flow probably leads to higher treatment failure within 72 hours of trial entry compared with continuous positive airway pressure (moderate certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Mechanical ventilation within 72 hours of trial entry · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in mechanical ventilation within 72 hours of trial entry compared with continuous positive airway pressure (moderate certainty).

1 finding from 1 review

HFNC vs nasal intermittent positive pressure ventilation

Death (before hospital discharge) or BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

It is very uncertain whether nasal high flow changes death (before hospital discharge) or BPD (supplemental… compared with nasal intermittent positive pressure ventilation (very low certainty).

1 finding from 1 review

Low tidal volume vs high tidal volume

All‐cause mortality · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

Low tidal volume showed no clear difference in mortality compared with high tidal volume (low certainty).

1 finding from 1 review

Low tidal volume vs high tidal volume

Pneumonia · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

Low tidal volume probably leads to lower pneumonia compared with high tidal volume (moderate certainty).

1 finding from 1 review

Low tidal volume vs high tidal volume

Need for postoperative non‐invasive ventilatory support · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

Low tidal volume probably leads to lower need for postoperative non‐invasive ventilatory support compared with high tidal volume (moderate certainty).

1 finding from 1 review

Low tidal volume vs high tidal volume

Need for postoperative invasive ventilatory support · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

Low tidal volume probably leads to lower need for postoperative invasive ventilatory support compared with high tidal volume (moderate certainty).

1 finding from 1 review

Low tidal volume vs high tidal volume

Barotrauma (pneumothorax) · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

It is very uncertain whether low tidal volume changes barotrauma: pneumothorax compared with high tidal volume (very low certainty).

1 finding from 1 review

Bonded Minne appliance (slow maxillary expansion) vs Banded Minne appliance (slow maxillary expansion)

Stability of crossbite correction (relapse of canine expansion) · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
1 finding from 1 review