Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

567 questions · 599 findings · 114 reviews

No studies found 136 · 22.7%GRADE not reported 45 · 7.5%Very low 166 · 27.7%Low 152 · 25.4%Moderate 75 · 12.5%High 25 · 4.2%

HFNC vs NIPPV or NIV

Treatment failure (escalation of respiratory therapy to NIV, NIPPV or invasive ventilation) Measured up to 28 days · adults in the ICU, requiring respiratory support

HFNC showed no clear difference in treatment failure (escalation of respiratory therapy to NIV, NIPPV… compared with NIPPV or NIV (low certainty).

1 finding from 1 review

HFNC vs NIPPV or NIV

In‐hospital mortality (up to 90 days; included studies reported in‐hospital mortality, and mortality up to 28 days and up to ICU discharge) · adults in the ICU, requiring respiratory support

HFNC showed no clear difference in in‐hospital mortality (up to 90 days; included studies reported… compared with NIPPV or NIV (low certainty).

1 finding from 1 review

Intervention not reported

Mortality at longest · adult (≥ 18 years of age) patients receiving mechanical ventilation (via either an endotracheal tube or a tracheostomy) for acute…

It is very uncertain whether the intervention changes mortality at longest (very low certainty).

1 finding from 1 review