Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,679 questions · 1,720 findings · 335 reviews · Headline outcomes only

No studies found 192 · 11.2%GRADE not reported 75 · 4.4%Very low 526 · 30.6%Low 504 · 29.3%Moderate 305 · 17.7%High 118 · 6.9%

Summary of findings table ‐ Progestogens vs GnRH antagonists

Oocyte pick‐up cancellation sensitivity analysis ‐ PCOS (high‐responders)(micronised progesterone 100 mg versus GnRH antagonists) ‐ Own oocytes ‐ Early phase stimulation protocol ‐ Frozen embryo transfer · assisted reproduction technology cycles

Summary of findings table ‐ Progestogens showed no clear difference in oocyte pick‐up cancellation sensitivity analysis ‐ PCOS… compared with gnRH antagonists; GRADE not reported.

1 finding from 1 review

Summary of findings table ‐ Progestogens vs GnRH antagonists

Clinical pregnancy · assisted reproduction technology cycles

Summary of findings table ‐ Progestogens showed no clear difference in clinical pregnancy ‐ Poor‐responders (MPA 10 mg versus GnRH… compared with gnRH antagonists (low certainty).

1 finding from 1 review

Summary of findings table ‐ Progestogens vs Progestogen 2

Oocyte pick‐up cancellation · assisted reproduction technology cycles

Summary of findings table ‐ Progestogen 1 showed no clear difference in oocyte pick‐up cancellation ‐ Normo‐responders (MPA 4 mg versus… compared with progestogen 2 (low certainty).

5 findings from 1 review
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Summary of findings table ‐ Progestogens vs Progestogen 2

Oocyte pick‐up cancellation ‐ Normo‐responders (Dydrogesterone 20 mg versus Micronised progesterone 100 mg) ‐ Own oocytes ‐ Early phase stimulation protocol · assisted reproduction technology cycles

Summary of findings table ‐ Progestogen 1 showed no clear difference in oocyte pick‐up cancellation ‐ Normo‐responders (Dydrogesterone 20 mg… compared with progestogen 2 (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Progestogens vs Progestogen 2

Clinical pregnancy · assisted reproduction technology cycles

Summary of findings table ‐ Progestogen 1 showed no clear difference in clinical pregnancy ‐ Normo‐responders (MPA 10 mg versus… compared with progestogen 2 (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Progestogens vs Progestogen 2

Miscarriage · assisted reproduction technology cycles

Summary of findings table ‐ Progestogen 1 showed no clear difference in miscarriage ‐ Miscarriage per randomised woman ‐ Normo‐responders… compared with progestogen 2 (low certainty).

1 finding from 1 review

Summary of findings table ‐ Progestogens vs GnRH antagonists

Live birth or ongoing pregnancy ‐ Poor‐responders (MPA 10 mg versus GnRH antagonists) ‐ Own oocytes ‐ Early phase stimulation protocol · assisted reproduction technology cycles

Summary of findings table ‐ Progestogens showed no clear difference in live birth or ongoing pregnancy ‐ Poor‐responders (MPA 10 mg versus… compared with gnRH antagonists; GRADE not reported.

1 finding from 1 review

Summary of findings table ‐ Progestogens vs GnRH antagonists

Oocyte pick‐up cancellation · assisted reproduction technology cycles

Summary of findings table ‐ Progestogens showed no clear difference in oocyte pick‐up cancellation ‐ Normoresponders (MPA 10 mg versus GnRH… compared with gnRH antagonists; GRADE not reported.

2 findings from 1 review

Cephalomedullary nails vs extramedullary implants

Functional status, early (within 4 months): using HHS (range from 0 to 100) and Johansen hip score (range from 0 to 100); higher scores indicate better function · older adults (> 60 years of age) with extracapsular hip fractures

Cephalomedullary nails showed no clear difference in functional status, early (≤ 4 months): using Zűckerman functional… compared with extramedullary implants (low certainty).

1 finding from 1 review

Cephalomedullary nails vs extramedullary implants

Mortality, early (≤ 4 months) · older adults (> 60 years of age) with extracapsular hip fractures

Cephalomedullary nails showed no clear difference in mortality, early (≤ 4 months) compared with extramedullary implants (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

C1: Total deaths (after randomisation) up to early childhood · the child

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids showed no clear difference in C1: Total deaths (after randomisation) up to early childhood compared with single course (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

C2: Neurodevelopmental impairment at early childhood · the child

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids showed no clear difference in C2: Neurodevelopmental impairment at early childhood compared with single course (high certainty).

1 finding from 1 review

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

C3: Survival free of neurodevelopmental impairment at early childhood · the child

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids showed no clear difference in C3: Survival free of neurodevelopmental impairment at early childhood compared with single course (high certainty).

1 finding from 1 review

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

C4: Survival free of major neurodevelopmental impairment atearly childhood · the child

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids showed no clear difference in C4: Survival free of major neurodevelopmental impairment atearly… compared with single course (moderate certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs IPC alone

Incidence of PEa (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

IPC plus pharmacological prophylaxis may leads to lower incidence of PEa (early postoperative period) compared with IPC alone (low certainty).

1 finding from 1 review