Findings

What do systematic reviews say?

445 questions · 449 findings · 45 reviews · Airways

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No studies found 35 · 7.8%GRADE not reported 26 · 5.8%Very low 30 · 6.7%Low 134 · 29.8%Moderate 160 · 35.6%High 64 · 14.3%

Ciclesonide vs fluticasone (dose ratio 1:2)

Adverse events Number of patients with adverse events · children with chronic asthma

It is very uncertain whether ciclesonide changes adverse events Number of patients with adverse events compared with fluticasone (dose ratio 1:2) (very low certainty).

1 finding from 1 review

Ciclesonide versus other inhaled corticosteroids for chronic asthma in children 2013 · Cochrane Headline outcomes only
RR 0.99 [0.89, 1.08]
1 study · 502 participants
Very low

Inhaled corticosteroids vs placebo

Hospital admissions · patients with acute asthma

ICS may leads to lower hospital admission compared with placebo (low certainty).

1 finding from 1 review

Early use of inhaled corticosteroids in the emergency department treatment of acute asthma 2012 · Cochrane Headline outcomes only
OR 0.44 [0.31, 0.61]
12 studies · 959 participants
Low

Inhaled corticosteroids vs placebo

FEV1 (L) · patients with acute asthma

ICS showed no clear difference in FEV1 at 1 hour compared with placebo (low certainty).

1 finding from 1 review

Early use of inhaled corticosteroids in the emergency department treatment of acute asthma 2012 · Cochrane Headline outcomes only
MD 0.28
4 studies · 248 participants
Low

Inhaled corticosteroids vs placebo

FEV1 · patients with acute asthma

ICS showed no clear difference in FEV1 at 3 to 4 hours compared with placebo (moderate certainty).

1 finding from 1 review

Early use of inhaled corticosteroids in the emergency department treatment of acute asthma 2012 · Cochrane Headline outcomes only
MD 0.15
4 studies · 319 participants
Moderate

Inhaled corticosteroids vs placebo

Nausea and vomiting · patients with acute asthma

ICS showed no clear difference in adverse effects ‐ nausea/vomiting compared with placebo (low certainty).

1 finding from 1 review

Early use of inhaled corticosteroids in the emergency department treatment of acute asthma 2012 · Cochrane Headline outcomes only
OR 0.32 [0.03, 3.18]
1 study · 94 participants
Low