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What do systematic reviews say?

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Evidence found and GRADE certainty

2,805 questions · 2,912 findings · 307 reviews · Headline outcomes only

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No studies found 706 · 24.2%GRADE not reported 133 · 4.6%Very low 786 · 27%Low 696 · 23.9%Moderate 474 · 16.3%High 117 · 4%

Antihypertensive drug therapy vs control

Withdrawals due to adverse events · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)

It is very uncertain whether antihypertensive drug therapy changes withdrawal due to adverse events compared with control (very low certainty).

1 finding from 1 review

Intervention not reported

Change in health‐related quality of life (SMD) Parent‐reported measures Instruments: PedsQL parent proxy: 23 items that yield total, physical summary, and psychosocial summary scores, each with a possible range of 0‐100 (100 = best possible health... · children (aged 6 to 11 years) being overweight or obese
1 finding from 1 review

Xylitol vs control

Final diagnosis of at least one episode of AOM · preventing acute otitis media in children up to 12 years of age

Xylitol probably leads to lower final diagnosis of at least one episode of AOM compared with control (moderate certainty).

3 findings from 1 review

Xylitol vs control

Hospitalisation ‐ not reported · preventing acute otitis media in children up to 12 years of age
3 findings from 1 review

Xylitol vs control

Mortality ‐ not reported · preventing acute otitis media in children up to 12 years of age
3 findings from 1 review

Xylitol vs control

Number of days missed at school or daycare ‐ not measured · preventing acute otitis media in children up to 12 years of age
3 findings from 1 review