Findings

What do systematic reviews say?

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

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No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Ceftriaxone vs penicillin G

Clinical cure assessed by RPR decrease · people with neurosyphilis

1 finding from 1 review

Antibiotic therapy for adults with neurosyphilis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 36 participants
Very low

Ceftriaxone vs penicillin G

Adverse events Any untoward medical occurrence regarding medications · people with neurosyphilis

1 finding from 1 review

Antibiotic therapy for adults with neurosyphilis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
Very low

Ceftriaxone vs penicillin G

Recurrence of neurosyphilis · people with neurosyphilis

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic therapy for adults with neurosyphilis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ceftriaxone vs penicillin G

Time to recovery · people with neurosyphilis

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic therapy for adults with neurosyphilis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ceftriaxone vs penicillin G

Quality of life · people with neurosyphilis

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic therapy for adults with neurosyphilis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ceftriaxone vs penicillin G

Treatment withdrawal · people with neurosyphilis

It is very uncertain whether ceftriaxone changes withdrawals compared with penicillin G (very low certainty).

1 finding from 1 review

Antibiotic therapy for adults with neurosyphilis 2019 · Cochrane Headline outcomes only
RR 2 [0.42, 9.48]
1 study · 36 participants
Very low

ECT plus standard care vs sham‐ECT plus standard care

Response to treatment (medium term) Clinically important response to treatment as defined by each study · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Electroconvulsive therapy for treatment‐resistant schizophrenia 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

ECT plus standard care vs antipsychotics plus standard care

Satisfaction with treatment: leaving the study early Endpoint data (events) · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Electroconvulsive therapy for treatment‐resistant schizophrenia 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

ECT plus standard care vs antipsychotics plus standard care

Mental state · people with treatment‐resistant schizophrenia

1 finding from 1 review

Electroconvulsive therapy for treatment‐resistant schizophrenia 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 162 participants
Very low

ECT plus standard care vs antipsychotics plus standard care

Functioning: clinically important change in general functioning, as defined by individual studies · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Electroconvulsive therapy for treatment‐resistant schizophrenia 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

ECT plus standard care vs antipsychotics plus standard care

Service outcomes: Hospitalisation · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Electroconvulsive therapy for treatment‐resistant schizophrenia 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

ECT plus standard care vs antipsychotics plus standard care

Adverse event/effect(s) ‐ death · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Electroconvulsive therapy for treatment‐resistant schizophrenia 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

ECT plus standard care vs usual care

Response to treatment (medium term) Clinically important response to treatment as defined by each study · people with treatment‐resistant schizophrenia

ECT plus standard care probably leads to higher response to treatment (medium term) Clinically important response to… compared with standard care (moderate certainty).

1 finding from 1 review

Electroconvulsive therapy for treatment‐resistant schizophrenia 2019 · Cochrane Headline outcomes only
RR 2.06 [1.75, 2.42]
9 studies · 819 participants
Moderate

ECT plus standard care vs usual care

Cognitive functioning (short term) ‐ memory deterioration · people with treatment‐resistant schizophrenia

It is very uncertain whether ECT plus standard care changes cognitive functioning (short term) ‐ memory deterioration compared with standard care (very low certainty).

1 finding from 1 review

Electroconvulsive therapy for treatment‐resistant schizophrenia 2019 · Cochrane Headline outcomes only
RR 27 [1.67, 437.68]
1 study · 72 participants
Very low

ECT plus standard care vs usual care

Satisfaction and acceptability of treatment (medium term) ‐ leaving the study early · people with treatment‐resistant schizophrenia

It is very uncertain whether ECT plus standard care changes satisfaction and acceptability of treatment (medium term) ‐ leaving… compared with standard care (very low certainty).

1 finding from 1 review

Electroconvulsive therapy for treatment‐resistant schizophrenia 2019 · Cochrane Headline outcomes only
RR 1.18 [0.38, 3.63]
3 studies · 354 participants
Very low

ECT plus standard care vs usual care

Mental state · people with treatment‐resistant schizophrenia

1 finding from 1 review

Electroconvulsive therapy for treatment‐resistant schizophrenia 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 345 participants
Low

ECT plus standard care vs usual care

General functioning: Average endpoint general functioning score (clinically improved) (no data) · people with treatment‐resistant schizophrenia

1 finding from 1 review

Electroconvulsive therapy for treatment‐resistant schizophrenia 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 97 participants
Very low

ECT plus standard care vs sham‐ECT plus standard care

Cognitive functioning Clinically important change in cognitive functioning as defined by each study · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Electroconvulsive therapy for treatment‐resistant schizophrenia 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

ECT plus standard care vs usual care

Service outcomes: Hospitalisation · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Electroconvulsive therapy for treatment‐resistant schizophrenia 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

ECT plus standard care vs usual care

Adverse event/effect(s) ‐ death · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Electroconvulsive therapy for treatment‐resistant schizophrenia 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found