Incidence of S pneumoniae Confirmed bacterial infection · children with SCD who have been receiving prophylactic penicillin for at least two years
Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in incidence of S pneumoniae Confirmed bacterial infection compared with continuation (low certainty).
1 finding from 1 review
Deaths · children with SCD who have been receiving prophylactic penicillin for at least two years
1 finding from 1 review
Nausea and vomiting · children with SCD who have been receiving prophylactic penicillin for at least two years
Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in adverse effects: incidences of nausea and vomiting compared with continuation (low certainty).
1 finding from 1 review
All‐cause mortality maximum · patients with coronary heart disease
Antibiotics showed no clear difference in all‐cause mortality at maximum compared with placebo or no intervention (high certainty).
1 finding from 1 review
Quality of life at 24±6 months · patients with coronary heart disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Cardiovascular mortality · patients with coronary heart disease
Antibiotics leads to higher cardiovascular mortality at 24±6 months compared with placebo or no intervention (high certainty).
2 findings from 1 review
Myocardial infarction · patients with coronary heart disease
Antibiotics showed no clear difference in myocardial infarction at 24±6 months compared with placebo or no intervention (moderate certainty).
2 findings from 1 review
Stroke · patients with coronary heart disease
Antibiotics showed no clear difference in stroke at 24±6 months compared with placebo or no intervention (high certainty).
2 findings from 1 review
Sudden cardiac death · patients with coronary heart disease
Antibiotics probably leads to higher sudden cardiac death at 24±6 months compared with placebo or no intervention (moderate certainty).
2 findings from 1 review
Serious adverse events maximum · patients with coronary heart disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life at maximum · patients with coronary heart disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
All‐cause mortality at 24±6 months · patients with coronary heart disease
Antibiotics leads to higher all‐cause mortality at 24±6 months compared with placebo or no intervention (high certainty).
1 finding from 1 review
Serious adverse event at 24±6 months · patients with coronary heart disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Surgical site infection · surgical patients
Clipping showed no clear difference in surgical site infection (SSIs) compared with no hair removal (low certainty).
1 finding from 1 review
Wound complications · surgical patients
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Length of stay · surgical patients
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Costs · surgical patients
1 finding from 1 review
Surgical site infection · surgical patients
Shaving probably leads to higher surgical site infection (SSI) compared with clipping (moderate certainty).
1 finding from 1 review
Wound complications · surgical patients
Shaving probably leads to higher wound complications compared with clipping (moderate certainty).
1 finding from 1 review
Length of stay · surgical patients
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found