Hypertension · Adults (general population)
Summary of findings table ‐ LSSS intervention showed no clear difference in hypertension compared with regular salt (low certainty).
1 finding from 1 review
Cardiovascular events · Adults (general population)
It is very uncertain whether summary of findings table ‐ LSSS intervention changes cardiovascular events: various compared with regular salt (very low certainty).
1 finding from 1 review
Cardiovascular events: non‐fatal stroke · Adults (general population)
Summary of findings table ‐ LSSS intervention showed no clear difference in cardiovascular events: non‐fatal stroke compared with regular salt (moderate certainty).
1 finding from 1 review
Cardiovascular events: non‐fatal acute coronary syndrome (events per 100,000 person‐years) · Adults (general population)
Summary of findings table ‐ LSSS intervention probably leads to lower cardiovascular events: non‐fatal acute coronary syndrome (events per… compared with regular salt (moderate certainty).
1 finding from 1 review
Cardiovascular mortality · Adults (general population)
Summary of findings table ‐ LSSS intervention showed no clear difference in cardiovascular mortality (events per 100,000 person‐years) compared with regular salt (moderate certainty).
1 finding from 1 review
Stroke mortality (events per 100,000 person‐years) · Adults (general population)
It is very uncertain whether summary of findings table ‐ LSSS intervention changes stroke mortality (events per 100,000 person‐years) compared with regular salt (very low certainty).
1 finding from 1 review
Development of >=1 new carious lesion (caries incidence) · Children with sound primary molars, aged 2-4 years (municipal dental clinics or hospital paediatric clinics, Denmark)
It is very uncertain whether autopolymerised sealant changes development of >=1 new carious lesion (caries incidence) compared with light polymerised sealant (very low certainty).
1 finding from 1 review
Change in data on economics and quality of life · Residents of nursing homes and other long-term care facilities
Professional oral care led to higher change in data on economics and quality of life compared with usual oral care; GRADE not reported.
1 finding from 1 review
Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
It is very uncertain whether tempered chlorhexidine changes reduction in level of contamination by particles >5 um (droplets) at… compared with non-tempered chlorhexidine (very low certainty).
3 findings from 1 review
MD -10.8 [-15.15, -6.45]
1 study · 20 participants
Very low
MD -17.6 [-23.7, -11.5]
1 study · 20 participants
Very low
MD -15.8 [-22.67, -8.93]
1 study · 20 participants
Very low
Adverse events due to periodontal therapy · Patients with cardiovascular disease and chronic periodontitis
1 finding from 1 review
Adverse events: because of variable follow-up (6 to 25 months) and almost 90% loss to follow-up by one year, results were not considered useful for analysis; uncertain whether adverse events are more likely with either…
1 study · 303 participants
GRADE not reported
Oral health indices · Residents of nursing homes and other long-term care facilities
Professional oral care led to higher oral health indices compared with usual oral care; GRADE not reported.
1 finding from 1 review
Development of >=1 new carious lesion (caries incidence) · Children who were regular dental attenders with caries-free first or second primary molars (public health service clinic, Brazil)
The review found no eligible studies for this question.
1 finding from 1 review
Progression of non-cavitated enamel caries · Children with sound primary molars, aged 2-4 years (municipal dental clinics or hospital paediatric clinics, Denmark)
The review found no eligible studies for this question.
1 finding from 1 review
Change in systemic antibiotic use · Residents of nursing homes and other long-term care facilities
The review found no eligible studies for this question.
1 finding from 1 review
Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
1 finding from 1 review
At operator level, because of high heterogeneity (I2 = 89%), which could not be explained, the results were not meta-analysed (2 studies, 60 participants; Feres 2010, Retamal-Valdes 2017). No pooled estimate or GRADE…
2 studies · 60 participants
GRADE not reported
Retention of sealant (complete or partial retention) · Children who were regular dental attenders with caries-free first or second primary molars (public health service clinic, Brazil)
1 finding from 1 review
Effect estimate not calculable. All sealants were completely or partially retained; 40 (1 RCT). Flowable composite: 39/40 completely retained (1 partially lost) at 6 months; resin-based: 33 completely and 7 partially…
1 study · 40 participants
Low
Serum high-sensitivity C-reactive protein (hs-CRP) · Patients with cardiovascular disease and chronic periodontitis
1 finding from 1 review
Serum hs-CRP tested at one year; as loss to follow-up was almost 90%, data not considered useful for analysis (no usable estimate).
1 study · 37 participants
GRADE not reported
Dental caries increment, DMFT/dmft (whole-tooth level) · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric clinic/dental school,…
1 finding from 1 review
Retention of sealant (complete or partial retention) · 'Healthy' children with caries-free second primary molars, aged 3-5 years (schools and kindergartens, India and China)
1 finding from 1 review
Adverse events · 'Healthy' children with caries-free second primary molars, aged 3-5 years (schools and kindergartens, India and China)
1 finding from 1 review
1 study reported adverse events as some discomfort such as nausea; 1 child experienced a strong gag reflex following the glass ionomer-based sealant while 8 children reported feeling uncomfortable after the fluoride…
1 study · 100 participants
Very low